Molecular Methods for the Diagnosis of Invasive Candidiasis
Invasive infections caused by members of the genus <i>Candida</i> are on the rise. Especially patients in intensive care units, immunocompromised patients, and those recovering from abdominal surgery are at risk for the development of candidemia or deep-seated candidiasis. Rapid initiati...
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doaj-77b3524dc85f462ba926a7c3c4983e7a2020-11-25T03:49:23ZengMDPI AGJournal of Fungi2309-608X2020-07-01610110110.3390/jof6030101Molecular Methods for the Diagnosis of Invasive CandidiasisIris Camp0Kathrin Spettel1Birgit Willinger2Division of Clinical Microbiology, Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, AustriaDivision of Clinical Microbiology, Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, AustriaDivision of Clinical Microbiology, Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, AustriaInvasive infections caused by members of the genus <i>Candida</i> are on the rise. Especially patients in intensive care units, immunocompromised patients, and those recovering from abdominal surgery are at risk for the development of candidemia or deep-seated candidiasis. Rapid initiation of appropriate antifungal therapy can increase survival rates significantly. In the past, most of these infections were caused by <i>C. albicans</i>, a species that typically is very susceptible to antifungals. However, in recent years a shift towards infections caused by non-albicans species displaying various susceptibly patterns has been observed and the prompt diagnosis of the underlying species has become an essential factor determining the therapeutic outcome. The gold standard for diagnosing invasive candidiasis is blood culture, even though its sensitivity is low and the time required for species identification usually exceeds 48 h. To overcome these issues, blood culture can be combined with other methods, and a large number of tests have been developed for this purpose. The aim of this review was to give an overview on strengths and limitations of currently available molecular methods for the diagnosis of invasive candidiasis.https://www.mdpi.com/2309-608X/6/3/101CandidainvasivediagnosismolecularcandidemiaT2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Iris Camp Kathrin Spettel Birgit Willinger |
spellingShingle |
Iris Camp Kathrin Spettel Birgit Willinger Molecular Methods for the Diagnosis of Invasive Candidiasis Journal of Fungi Candida invasive diagnosis molecular candidemia T2 |
author_facet |
Iris Camp Kathrin Spettel Birgit Willinger |
author_sort |
Iris Camp |
title |
Molecular Methods for the Diagnosis of Invasive Candidiasis |
title_short |
Molecular Methods for the Diagnosis of Invasive Candidiasis |
title_full |
Molecular Methods for the Diagnosis of Invasive Candidiasis |
title_fullStr |
Molecular Methods for the Diagnosis of Invasive Candidiasis |
title_full_unstemmed |
Molecular Methods for the Diagnosis of Invasive Candidiasis |
title_sort |
molecular methods for the diagnosis of invasive candidiasis |
publisher |
MDPI AG |
series |
Journal of Fungi |
issn |
2309-608X |
publishDate |
2020-07-01 |
description |
Invasive infections caused by members of the genus <i>Candida</i> are on the rise. Especially patients in intensive care units, immunocompromised patients, and those recovering from abdominal surgery are at risk for the development of candidemia or deep-seated candidiasis. Rapid initiation of appropriate antifungal therapy can increase survival rates significantly. In the past, most of these infections were caused by <i>C. albicans</i>, a species that typically is very susceptible to antifungals. However, in recent years a shift towards infections caused by non-albicans species displaying various susceptibly patterns has been observed and the prompt diagnosis of the underlying species has become an essential factor determining the therapeutic outcome. The gold standard for diagnosing invasive candidiasis is blood culture, even though its sensitivity is low and the time required for species identification usually exceeds 48 h. To overcome these issues, blood culture can be combined with other methods, and a large number of tests have been developed for this purpose. The aim of this review was to give an overview on strengths and limitations of currently available molecular methods for the diagnosis of invasive candidiasis. |
topic |
Candida invasive diagnosis molecular candidemia T2 |
url |
https://www.mdpi.com/2309-608X/6/3/101 |
work_keys_str_mv |
AT iriscamp molecularmethodsforthediagnosisofinvasivecandidiasis AT kathrinspettel molecularmethodsforthediagnosisofinvasivecandidiasis AT birgitwillinger molecularmethodsforthediagnosisofinvasivecandidiasis |
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