In vitro anti-oxidant and cytotoxic analysis of Pogostemon mollis Benth
In the present study, the anti-oxidant and cytotoxic effects of the different solvent extracts of Pogostemon mollis were analyzed. The phenolic, tannin and flavonoid contents were highest in the ethyl acetate extract and analogous to the antioxidant activity results. The extracts showed activities s...
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Bangladesh Pharmacological Society
2016-01-01
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| Series: | Bangladesh Journal of Pharmacology |
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| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/24157 |
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doaj-77b3c867f68644cbab30a496528f28182020-11-24T21:54:00ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882016-01-0111110.3329/bjp.v11i1.24157In vitro anti-oxidant and cytotoxic analysis of Pogostemon mollis BenthElizabeth George0Muniyandi Kasipandi1Mudili Vekataramana2Kalagatur Naveen Kumar3Joseph Anthuvan Allen4Thangaraj Parimelazhagan5Natarajan Gopalan6Department of Botany, Bharathiar University, CoimbatoreDepartment of Botany, Bharathiar University, CoimbatoreDRDO-Bharathiar University Centre for Life Sciences, CoimbatoreDefence Food Research Laboratory, MysoreDRDO-Bharathiar University Centre for Life Sciences, CoimbatoreDepartment of Botany, Bharathiar University, CoimbatoreDRDO-Bharathiar University Centre for Life Sciences, CoimbatoreIn the present study, the anti-oxidant and cytotoxic effects of the different solvent extracts of Pogostemon mollis were analyzed. The phenolic, tannin and flavonoid contents were highest in the ethyl acetate extract and analogous to the antioxidant activity results. The extracts showed activities similar to the standard anti-oxidants. The extent to which the extracts protect free radical damage on DNA was evaluated and showed good genoprotective effects. Bacterial cells and fungal spores and hyphae showed visible damages due to the treatment of ethyl acetate extract. Finally, in the cytotoxic analysis, IC50 value was calculated based on the absorbance value of different concentrations. It concluded that P. mollis is a prospective candidate for the various therapeutic applications especially its ethyl acetate extract. https://www.banglajol.info/index.php/BJP/article/view/24157Anti-oxidantCytotoxicPogostemon mollis |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Elizabeth George Muniyandi Kasipandi Mudili Vekataramana Kalagatur Naveen Kumar Joseph Anthuvan Allen Thangaraj Parimelazhagan Natarajan Gopalan |
| spellingShingle |
Elizabeth George Muniyandi Kasipandi Mudili Vekataramana Kalagatur Naveen Kumar Joseph Anthuvan Allen Thangaraj Parimelazhagan Natarajan Gopalan In vitro anti-oxidant and cytotoxic analysis of Pogostemon mollis Benth Bangladesh Journal of Pharmacology Anti-oxidant Cytotoxic Pogostemon mollis |
| author_facet |
Elizabeth George Muniyandi Kasipandi Mudili Vekataramana Kalagatur Naveen Kumar Joseph Anthuvan Allen Thangaraj Parimelazhagan Natarajan Gopalan |
| author_sort |
Elizabeth George |
| title |
In vitro anti-oxidant and cytotoxic analysis of Pogostemon mollis Benth |
| title_short |
In vitro anti-oxidant and cytotoxic analysis of Pogostemon mollis Benth |
| title_full |
In vitro anti-oxidant and cytotoxic analysis of Pogostemon mollis Benth |
| title_fullStr |
In vitro anti-oxidant and cytotoxic analysis of Pogostemon mollis Benth |
| title_full_unstemmed |
In vitro anti-oxidant and cytotoxic analysis of Pogostemon mollis Benth |
| title_sort |
in vitro anti-oxidant and cytotoxic analysis of pogostemon mollis benth |
| publisher |
Bangladesh Pharmacological Society |
| series |
Bangladesh Journal of Pharmacology |
| issn |
1991-0088 |
| publishDate |
2016-01-01 |
| description |
In the present study, the anti-oxidant and cytotoxic effects of the different solvent extracts of Pogostemon mollis were analyzed. The phenolic, tannin and flavonoid contents were highest in the ethyl acetate extract and analogous to the antioxidant activity results. The extracts showed activities similar to the standard anti-oxidants. The extent to which the extracts protect free radical damage on DNA was evaluated and showed good genoprotective effects. Bacterial cells and fungal spores and hyphae showed visible damages due to the treatment of ethyl acetate extract. Finally, in the cytotoxic analysis, IC50 value was calculated based on the absorbance value of different concentrations. It concluded that P. mollis is a prospective candidate for the various therapeutic applications especially its ethyl acetate extract.
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| topic |
Anti-oxidant Cytotoxic Pogostemon mollis |
| url |
https://www.banglajol.info/index.php/BJP/article/view/24157 |
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