Critical appraisal on the use of everolimus in renal transplantation as an immunosuppressant to prevent organ transplant rejection
Fernando Giron, Yenny BaezKidney Transplant Service, Colombiana de Trasplantes, Bogota, ColombiaAbstract: Everolimus is a proliferation inhibitor designed to target chronic allograft nephropathy including prevention of acute rejection. Acute renal allograft rejection incidence varies with the therap...
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2010-01-01
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doaj-77c80ceec10f4149bec750d58ecb287e2020-11-24T21:22:27ZengDove Medical PressTransplant Research and Risk Management1179-16162010-01-012010default1114Critical appraisal on the use of everolimus in renal transplantation as an immunosuppressant to prevent organ transplant rejectionFernando GironYenny BaezFernando Giron, Yenny BaezKidney Transplant Service, Colombiana de Trasplantes, Bogota, ColombiaAbstract: Everolimus is a proliferation inhibitor designed to target chronic allograft nephropathy including prevention of acute rejection. Acute renal allograft rejection incidence varies with the therapy used for immunosuppression. Registry data show that 15% to 35% of kidney recipients will undergo treatment for at least one episode of acute rejection within the first post-transplant year. Everolimus has been used as therapy with full- or reduced-dose cyclosporine A without evidence of increasing the acute rejection incidence. This review will summarize the available clinical trial data on the use of everolimus and its role in preventing acute rejection incidence in renal transplantation.Keywords: calcineurin inhibitors, cyclosporine, everolimus, biopsy-proven acute rejection, renal transplantation, acute rejection http://www.dovepress.com/critical-appraisal-on-the-use-of-everolimus-in-renal-transplantation-a-a3919 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fernando Giron Yenny Baez |
spellingShingle |
Fernando Giron Yenny Baez Critical appraisal on the use of everolimus in renal transplantation as an immunosuppressant to prevent organ transplant rejection Transplant Research and Risk Management |
author_facet |
Fernando Giron Yenny Baez |
author_sort |
Fernando Giron |
title |
Critical appraisal on the use of everolimus in renal transplantation as an immunosuppressant to prevent organ transplant rejection |
title_short |
Critical appraisal on the use of everolimus in renal transplantation as an immunosuppressant to prevent organ transplant rejection |
title_full |
Critical appraisal on the use of everolimus in renal transplantation as an immunosuppressant to prevent organ transplant rejection |
title_fullStr |
Critical appraisal on the use of everolimus in renal transplantation as an immunosuppressant to prevent organ transplant rejection |
title_full_unstemmed |
Critical appraisal on the use of everolimus in renal transplantation as an immunosuppressant to prevent organ transplant rejection |
title_sort |
critical appraisal on the use of everolimus in renal transplantation as an immunosuppressant to prevent organ transplant rejection |
publisher |
Dove Medical Press |
series |
Transplant Research and Risk Management |
issn |
1179-1616 |
publishDate |
2010-01-01 |
description |
Fernando Giron, Yenny BaezKidney Transplant Service, Colombiana de Trasplantes, Bogota, ColombiaAbstract: Everolimus is a proliferation inhibitor designed to target chronic allograft nephropathy including prevention of acute rejection. Acute renal allograft rejection incidence varies with the therapy used for immunosuppression. Registry data show that 15% to 35% of kidney recipients will undergo treatment for at least one episode of acute rejection within the first post-transplant year. Everolimus has been used as therapy with full- or reduced-dose cyclosporine A without evidence of increasing the acute rejection incidence. This review will summarize the available clinical trial data on the use of everolimus and its role in preventing acute rejection incidence in renal transplantation.Keywords: calcineurin inhibitors, cyclosporine, everolimus, biopsy-proven acute rejection, renal transplantation, acute rejection |
url |
http://www.dovepress.com/critical-appraisal-on-the-use-of-everolimus-in-renal-transplantation-a-a3919 |
work_keys_str_mv |
AT fernandogiron criticalappraisalontheuseofeverolimusinrenaltransplantationasanimmunosuppressanttopreventorgantransplantrejection AT yennybaez criticalappraisalontheuseofeverolimusinrenaltransplantationasanimmunosuppressanttopreventorgantransplantrejection |
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