Evaluation of the perioperative period of orthotopic liver transplantation with veno-venous bypass and without it

• Main Authors: D. A. Levit, N. A. Dobrynina, E. A. Chvanov, Yu. I. Petrishchev, O. G. Orlov, M. I. Prudkov, N. F. Klimusheva, A. L. Levit
• Format: Article
• Language: Russian
• Published: Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov 2017-04-01
• Series: Vestnik Transplantologii i Iskusstvennyh Organov
• Subjects: orthotopic liver transplantation; veno-venous bypass; duration of mechanical ventilation
• Online Access: https://journal.transpl.ru/vtio/article/view/726

Orthotopic liver transplantation (OLT) is the only treatment for many patients with end-stage chronic liver diseases. In patients with complete vena cava inferior (VCI) cross-clamping veno-venous bypass (VVB) is either used or not depending on the indications. The case management of the patient with complete VCI cross-clamping depends on the initial state of the recipient and the transplant team’s opinion.Aim. To compare the perioperative period of OLT depending on the method to conduct the main stage of the surgery: with the use of veno-venous bypass and without it with complete VCI cross-clamping.Materials and methods. In Group 1 (n = 20), OLT was performed without VVB with complete VCI cross-clamping; in Group 2 (n = 26), the surgery was conducted with veno-venous bypass. Patients in both groups were similar in age (46.15 ± 10.22 and 47.3 ± 9.29, respectively), in severity of the disease: Child-Pugh (10.15 ± 1.42 and 10.19 ± 2.45), MELD 16.47 ± 4.41 and 15.8 ± 4.95).Results. We determined and evaluated hemodynamic parameters, oxygen transport, the quantitative and qualitative infusion composition, urine output, characteristics of the postoperative period.Conclusion. Our data show that changes in hemodynamic and oxygen transport are associated with reperfusion syndrome and do not depend on the method of transplantation. At the same time, it reduces the blood loss, time of surgery, and the duration of postoperative mechanical ventilation and stay in the ICU after liver transplantation in patients without veno-venous bypass.