From Pathology to Precision Medicine in Anaplastic Large Cell Lymphoma Expressing Anaplastic Lymphoma Kinase (ALK+ ALCL)
Anaplastic large cell lymphoma expressing anaplastic lymphoma kinase (ALK+ ALCL) is a distinct subtype of non-Hodgkin lymphoma. In this review, we discuss the historical findings that led to its classification as a unique disease, despite its varied clinical presentation and histology. We discuss th...
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MDPI AG
2017-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/9/10/138 |
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doaj-77e7bd843f624e67b4e8eb99acc08fa92020-11-25T00:09:36ZengMDPI AGCancers2072-66942017-10-0191013810.3390/cancers9100138cancers9100138From Pathology to Precision Medicine in Anaplastic Large Cell Lymphoma Expressing Anaplastic Lymphoma Kinase (ALK+ ALCL)Michael T. Werner0Qian Zhang1Mariusz A. Wasik2Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USAAnaplastic large cell lymphoma expressing anaplastic lymphoma kinase (ALK+ ALCL) is a distinct subtype of non-Hodgkin lymphoma. In this review, we discuss the historical findings that led to its classification as a unique disease, despite its varied clinical presentation and histology. We discuss the molecular mechanisms underlying ALK+ ALCL pathology and the questions that remain in the field. Finally, we visit how decades of ALK+ ALCL research has yielded more precise drugs that hold promise for the future.https://www.mdpi.com/2072-6694/9/10/138anaplastic lymphoma kinaseanaplastic large cell lymphomaNPM-ALKALK+ ALCLprecision medicine |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Michael T. Werner Qian Zhang Mariusz A. Wasik |
| spellingShingle |
Michael T. Werner Qian Zhang Mariusz A. Wasik From Pathology to Precision Medicine in Anaplastic Large Cell Lymphoma Expressing Anaplastic Lymphoma Kinase (ALK+ ALCL) Cancers anaplastic lymphoma kinase anaplastic large cell lymphoma NPM-ALK ALK+ ALCL precision medicine |
| author_facet |
Michael T. Werner Qian Zhang Mariusz A. Wasik |
| author_sort |
Michael T. Werner |
| title |
From Pathology to Precision Medicine in Anaplastic Large Cell Lymphoma Expressing Anaplastic Lymphoma Kinase (ALK+ ALCL) |
| title_short |
From Pathology to Precision Medicine in Anaplastic Large Cell Lymphoma Expressing Anaplastic Lymphoma Kinase (ALK+ ALCL) |
| title_full |
From Pathology to Precision Medicine in Anaplastic Large Cell Lymphoma Expressing Anaplastic Lymphoma Kinase (ALK+ ALCL) |
| title_fullStr |
From Pathology to Precision Medicine in Anaplastic Large Cell Lymphoma Expressing Anaplastic Lymphoma Kinase (ALK+ ALCL) |
| title_full_unstemmed |
From Pathology to Precision Medicine in Anaplastic Large Cell Lymphoma Expressing Anaplastic Lymphoma Kinase (ALK+ ALCL) |
| title_sort |
from pathology to precision medicine in anaplastic large cell lymphoma expressing anaplastic lymphoma kinase (alk+ alcl) |
| publisher |
MDPI AG |
| series |
Cancers |
| issn |
2072-6694 |
| publishDate |
2017-10-01 |
| description |
Anaplastic large cell lymphoma expressing anaplastic lymphoma kinase (ALK+ ALCL) is a distinct subtype of non-Hodgkin lymphoma. In this review, we discuss the historical findings that led to its classification as a unique disease, despite its varied clinical presentation and histology. We discuss the molecular mechanisms underlying ALK+ ALCL pathology and the questions that remain in the field. Finally, we visit how decades of ALK+ ALCL research has yielded more precise drugs that hold promise for the future. |
| topic |
anaplastic lymphoma kinase anaplastic large cell lymphoma NPM-ALK ALK+ ALCL precision medicine |
| url |
https://www.mdpi.com/2072-6694/9/10/138 |
| work_keys_str_mv |
AT michaeltwerner frompathologytoprecisionmedicineinanaplasticlargecelllymphomaexpressinganaplasticlymphomakinasealkalcl AT qianzhang frompathologytoprecisionmedicineinanaplasticlargecelllymphomaexpressinganaplasticlymphomakinasealkalcl AT mariuszawasik frompathologytoprecisionmedicineinanaplasticlargecelllymphomaexpressinganaplasticlymphomakinasealkalcl |
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1725411043878895616 |