Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
Histone acetylation plays an important role in regulation of transcription in eukaryotic cells by promoting a more relaxed chromatin structure necessary for transcriptional activation. Histone deacetylases (HDACs) remove acetyl groups and suppress gene expression. HDAC inhibitors (HDACIs) are a grou...
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2013-01-01
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doaj-77f451ce75dd4653945f7c7765c5a9bb2020-11-25T01:25:02ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-46852013-01-0136329930710.1590/S1415-47572013000300001S1415-47572013000300001Histone deacetylase inhibitors as potential treatment for spinal muscular atrophyJafar Mohseni0Z.A.M.H. Zabidi-Hussin1Teguh Haryo Sasongko2Universiti Sains MalaysiaUniversiti Sains MalaysiaUniversiti Sains MalaysiaHistone acetylation plays an important role in regulation of transcription in eukaryotic cells by promoting a more relaxed chromatin structure necessary for transcriptional activation. Histone deacetylases (HDACs) remove acetyl groups and suppress gene expression. HDAC inhibitors (HDACIs) are a group of small molecules that promote gene transcription by chromatin remodeling and have been extensively studied as potential drugs for treating of spinal muscular atrophy. Various drugs in this class have been studied with regard to their efficacy in increasing the expression of survival of motor neuron (SMN) protein. In this review, we discuss the current literature on this topic and summarize the findings of the main studies in this field.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000300001&lng=en&tlng=enHDACimolecular therapyspinal muscular atrophy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jafar Mohseni Z.A.M.H. Zabidi-Hussin Teguh Haryo Sasongko |
spellingShingle |
Jafar Mohseni Z.A.M.H. Zabidi-Hussin Teguh Haryo Sasongko Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy Genetics and Molecular Biology HDACi molecular therapy spinal muscular atrophy |
author_facet |
Jafar Mohseni Z.A.M.H. Zabidi-Hussin Teguh Haryo Sasongko |
author_sort |
Jafar Mohseni |
title |
Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy |
title_short |
Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy |
title_full |
Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy |
title_fullStr |
Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy |
title_full_unstemmed |
Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy |
title_sort |
histone deacetylase inhibitors as potential treatment for spinal muscular atrophy |
publisher |
Sociedade Brasileira de Genética |
series |
Genetics and Molecular Biology |
issn |
1678-4685 |
publishDate |
2013-01-01 |
description |
Histone acetylation plays an important role in regulation of transcription in eukaryotic cells by promoting a more relaxed chromatin structure necessary for transcriptional activation. Histone deacetylases (HDACs) remove acetyl groups and suppress gene expression. HDAC inhibitors (HDACIs) are a group of small molecules that promote gene transcription by chromatin remodeling and have been extensively studied as potential drugs for treating of spinal muscular atrophy. Various drugs in this class have been studied with regard to their efficacy in increasing the expression of survival of motor neuron (SMN) protein. In this review, we discuss the current literature on this topic and summarize the findings of the main studies in this field. |
topic |
HDACi molecular therapy spinal muscular atrophy |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000300001&lng=en&tlng=en |
work_keys_str_mv |
AT jafarmohseni histonedeacetylaseinhibitorsaspotentialtreatmentforspinalmuscularatrophy AT zamhzabidihussin histonedeacetylaseinhibitorsaspotentialtreatmentforspinalmuscularatrophy AT teguhharyosasongko histonedeacetylaseinhibitorsaspotentialtreatmentforspinalmuscularatrophy |
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1725115596911149056 |