GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment

GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment

Polypeptide N-acetyl-galactosaminyltransferases (GALNTs) are associated with cancer, but their function in organ-specific metastasis is unclear. Here the authors show that GALNT14 promotes breast cancer metastasis to the lung by enhancing the initiation of metastatic colonies and subsequent growth.

Bibliographic Details
Main Authors: Ki-Hoon Song, Mi So Park, Tulip S. Nandu, Shrikanth Gadad, Sang-Cheol Kim, Mi-Young Kim
Format: Article
Language:English
Published: Nature Publishing Group 2016-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13796
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spelling doaj-77fddd8454574a1a8462112cfbaa46672021-05-11T11:14:52ZengNature Publishing GroupNature Communications2041-17232016-12-017111510.1038/ncomms13796GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironmentKi-Hoon Song0Mi So Park1Tulip S. Nandu2Shrikanth Gadad3Sang-Cheol Kim4Mi-Young Kim5Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical CenterCecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical CenterDepartment of Biomedical Informatics, Center for Genome Science, National Institute of Health, KCDCDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)Polypeptide N-acetyl-galactosaminyltransferases (GALNTs) are associated with cancer, but their function in organ-specific metastasis is unclear. Here the authors show that GALNT14 promotes breast cancer metastasis to the lung by enhancing the initiation of metastatic colonies and subsequent growth.https://doi.org/10.1038/ncomms13796
collection DOAJ
language English
format Article
sources DOAJ
author Ki-Hoon Song
Mi So Park
Tulip S. Nandu
Shrikanth Gadad
Sang-Cheol Kim
Mi-Young Kim
spellingShingle Ki-Hoon Song
Mi So Park
Tulip S. Nandu
Shrikanth Gadad
Sang-Cheol Kim
Mi-Young Kim
GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment
Nature Communications
author_facet Ki-Hoon Song
Mi So Park
Tulip S. Nandu
Shrikanth Gadad
Sang-Cheol Kim
Mi-Young Kim
author_sort Ki-Hoon Song
title GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment
title_short GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment
title_full GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment
title_fullStr GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment
title_full_unstemmed GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment
title_sort galnt14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-12-01
description Polypeptide N-acetyl-galactosaminyltransferases (GALNTs) are associated with cancer, but their function in organ-specific metastasis is unclear. Here the authors show that GALNT14 promotes breast cancer metastasis to the lung by enhancing the initiation of metastatic colonies and subsequent growth.
url https://doi.org/10.1038/ncomms13796
work_keys_str_mv AT kihoonsong galnt14promoteslungspecificbreastcancermetastasisbymodulatingselfrenewalandinteractionwiththelungmicroenvironment
AT misopark galnt14promoteslungspecificbreastcancermetastasisbymodulatingselfrenewalandinteractionwiththelungmicroenvironment
AT tulipsnandu galnt14promoteslungspecificbreastcancermetastasisbymodulatingselfrenewalandinteractionwiththelungmicroenvironment
AT shrikanthgadad galnt14promoteslungspecificbreastcancermetastasisbymodulatingselfrenewalandinteractionwiththelungmicroenvironment
AT sangcheolkim galnt14promoteslungspecificbreastcancermetastasisbymodulatingselfrenewalandinteractionwiththelungmicroenvironment
AT miyoungkim galnt14promoteslungspecificbreastcancermetastasisbymodulatingselfrenewalandinteractionwiththelungmicroenvironment
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