Increased Progesterone/Estradiol Ratio on the Day of hCG Administration Adversely Affects Success of In Vitro Fertilization–Embryo Transfer in Patients Stimulated with Gonadotropin-releasing Hormone Agonist and Recombinant Follicle-stimulating Hormone
Objective: We investigated the influence of premature luteinization in in vitro fertilization using a long protocol of gonadotropin-releasing hormone agonist (GnRHa) and recombinant follicle-stimulating hormone (rFSH), taking ovarian response into account in the definition of premature luteinization...
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doaj-78010b56c20d4e4989397d207876755c2020-11-24T23:57:58ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592008-06-0147216817410.1016/S1028-4559(08)60075-3Increased Progesterone/Estradiol Ratio on the Day of hCG Administration Adversely Affects Success of In Vitro Fertilization–Embryo Transfer in Patients Stimulated with Gonadotropin-releasing Hormone Agonist and Recombinant Follicle-stimulating HormoneYu-Che Ou0Kuo-Chung Lan1Shiuh-Young Chang2Fu-Tsai Kung3Fu-Jen Huang4Chang Gung Memorial Hospital—Kaohsiung Medical Center, Chang Cung University College of Medicine, Kaohsiung, TaiwanChang Gung Memorial Hospital—Kaohsiung Medical Center, Chang Cung University College of Medicine, Kaohsiung, TaiwanChang Gung Memorial Hospital—Kaohsiung Medical Center, Chang Cung University College of Medicine, Kaohsiung, TaiwanChang Gung Memorial Hospital—Kaohsiung Medical Center, Chang Cung University College of Medicine, Kaohsiung, TaiwanChang Gung Memorial Hospital—Kaohsiung Medical Center, Chang Cung University College of Medicine, Kaohsiung, TaiwanObjective: We investigated the influence of premature luteinization in in vitro fertilization using a long protocol of gonadotropin-releasing hormone agonist (GnRHa) and recombinant follicle-stimulating hormone (rFSH), taking ovarian response into account in the definition of premature luteinization. Materials and Methods: A total of 339 cycles of controlled ovarian hyperstimulation with rFSH and GnRHa were performed in 311 infertile couples. Premature luteinization was defined as a progesterone (P) to estradiol (E2) ratio of > 1 on the day of human chorionic gonadotropin (hCG) administration. The P/E2 ratio is calculated as: P (ng/mL) × 1,000/E2 (pg/mL). Clinical outcomes were compared for the prematurely luteinized and non-prematurely luteinized groups. Results: The mean number of retrieved oocytes, recovered mature oocytes, embryos and top quality embryos were significantly higher in the non-prematurely luteinized group than in the prematurely luteinized group. Although fertilization rates and implantation rates were similar between the two groups, the clinical pregnancy rate was higher in the non-prematurely luteinized group than in the prematurely luteinized group. Conclusion: Premature luteinization, defined as late follicular P/E2 ratio of > 1 in long GnRHa cycles with rFSH stimulation, adversely affected ovarian responses and clinical outcomes. It seems unrelated to preovulatory luteinizing hormone (LH) elevation and LH/hCG content of gonadotropins and could be associated with poor ovarian response and the presence of dysmature follicles. [Taiwan J Obstet Cynecol 2008;47(2):1 68-1 74]http://www.sciencedirect.com/science/article/pii/S1028455908600753GnRH agonistpremature luteinizationprogesterone to estradiol ratiorecombinant FSH |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu-Che Ou Kuo-Chung Lan Shiuh-Young Chang Fu-Tsai Kung Fu-Jen Huang |
spellingShingle |
Yu-Che Ou Kuo-Chung Lan Shiuh-Young Chang Fu-Tsai Kung Fu-Jen Huang Increased Progesterone/Estradiol Ratio on the Day of hCG Administration Adversely Affects Success of In Vitro Fertilization–Embryo Transfer in Patients Stimulated with Gonadotropin-releasing Hormone Agonist and Recombinant Follicle-stimulating Hormone Taiwanese Journal of Obstetrics & Gynecology GnRH agonist premature luteinization progesterone to estradiol ratio recombinant FSH |
author_facet |
Yu-Che Ou Kuo-Chung Lan Shiuh-Young Chang Fu-Tsai Kung Fu-Jen Huang |
author_sort |
Yu-Che Ou |
title |
Increased Progesterone/Estradiol Ratio on the Day of hCG Administration Adversely Affects Success of In Vitro Fertilization–Embryo Transfer in Patients Stimulated with Gonadotropin-releasing Hormone Agonist and Recombinant Follicle-stimulating Hormone |
title_short |
Increased Progesterone/Estradiol Ratio on the Day of hCG Administration Adversely Affects Success of In Vitro Fertilization–Embryo Transfer in Patients Stimulated with Gonadotropin-releasing Hormone Agonist and Recombinant Follicle-stimulating Hormone |
title_full |
Increased Progesterone/Estradiol Ratio on the Day of hCG Administration Adversely Affects Success of In Vitro Fertilization–Embryo Transfer in Patients Stimulated with Gonadotropin-releasing Hormone Agonist and Recombinant Follicle-stimulating Hormone |
title_fullStr |
Increased Progesterone/Estradiol Ratio on the Day of hCG Administration Adversely Affects Success of In Vitro Fertilization–Embryo Transfer in Patients Stimulated with Gonadotropin-releasing Hormone Agonist and Recombinant Follicle-stimulating Hormone |
title_full_unstemmed |
Increased Progesterone/Estradiol Ratio on the Day of hCG Administration Adversely Affects Success of In Vitro Fertilization–Embryo Transfer in Patients Stimulated with Gonadotropin-releasing Hormone Agonist and Recombinant Follicle-stimulating Hormone |
title_sort |
increased progesterone/estradiol ratio on the day of hcg administration adversely affects success of in vitro fertilization–embryo transfer in patients stimulated with gonadotropin-releasing hormone agonist and recombinant follicle-stimulating hormone |
publisher |
Elsevier |
series |
Taiwanese Journal of Obstetrics & Gynecology |
issn |
1028-4559 |
publishDate |
2008-06-01 |
description |
Objective: We investigated the influence of premature luteinization in in vitro fertilization using a long protocol of gonadotropin-releasing hormone agonist (GnRHa) and recombinant follicle-stimulating hormone (rFSH), taking ovarian response into account in the definition of premature luteinization.
Materials and Methods: A total of 339 cycles of controlled ovarian hyperstimulation with rFSH and GnRHa were performed in 311 infertile couples. Premature luteinization was defined as a progesterone (P) to estradiol (E2) ratio of > 1 on the day of human chorionic gonadotropin (hCG) administration. The P/E2 ratio is calculated as: P (ng/mL) × 1,000/E2 (pg/mL). Clinical outcomes were compared for the prematurely luteinized and non-prematurely luteinized groups.
Results: The mean number of retrieved oocytes, recovered mature oocytes, embryos and top quality embryos were significantly higher in the non-prematurely luteinized group than in the prematurely luteinized group. Although fertilization rates and implantation rates were similar between the two groups, the clinical pregnancy rate was higher in the non-prematurely luteinized group than in the prematurely luteinized group.
Conclusion: Premature luteinization, defined as late follicular P/E2 ratio of > 1 in long GnRHa cycles with rFSH stimulation, adversely affected ovarian responses and clinical outcomes. It seems unrelated to preovulatory luteinizing hormone (LH) elevation and LH/hCG content of gonadotropins and could be associated with poor ovarian response and the presence of dysmature follicles. [Taiwan J Obstet Cynecol 2008;47(2):1 68-1 74] |
topic |
GnRH agonist premature luteinization progesterone to estradiol ratio recombinant FSH |
url |
http://www.sciencedirect.com/science/article/pii/S1028455908600753 |
work_keys_str_mv |
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