New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp.
Pinnigorgiols D (1) and E (2), two new 9,11-secosterols with a rearranged carbon skeleton, were isolated from a Taiwan gorgonian Pinnigorgia sp. The structures of these two compounds were elucidated on the basis of spectroscopic methods and were proven to possess a tricyclo[5,2,1,1]decane ring. The...
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MDPI AG
2016-11-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/14/12/218 |
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doaj-780f57e027064521adcfe094f97b29722020-11-24T22:17:58ZengMDPI AGMarine Drugs1660-33972016-11-01141221810.3390/md14120218md14120218New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp.Yu-Chia Chang0Tsong-Long Hwang1Jyh-Horng Sheu2Yang-Chang Wu3Ping-Jyun Sung4National Museum of Marine Biology and Aquarium, Pingtung 944, TaiwanGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanSchool of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944, TaiwanPinnigorgiols D (1) and E (2), two new 9,11-secosterols with a rearranged carbon skeleton, were isolated from a Taiwan gorgonian Pinnigorgia sp. The structures of these two compounds were elucidated on the basis of spectroscopic methods and were proven to possess a tricyclo[5,2,1,1]decane ring. The new secosterols 1 and 2 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.http://www.mdpi.com/1660-3397/14/12/2189,11-secosterolgorgonianPinnigorgiaanti-inflammatorysuperoxide anionelastase |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yu-Chia Chang Tsong-Long Hwang Jyh-Horng Sheu Yang-Chang Wu Ping-Jyun Sung |
| spellingShingle |
Yu-Chia Chang Tsong-Long Hwang Jyh-Horng Sheu Yang-Chang Wu Ping-Jyun Sung New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp. Marine Drugs 9,11-secosterol gorgonian Pinnigorgia anti-inflammatory superoxide anion elastase |
| author_facet |
Yu-Chia Chang Tsong-Long Hwang Jyh-Horng Sheu Yang-Chang Wu Ping-Jyun Sung |
| author_sort |
Yu-Chia Chang |
| title |
New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp. |
| title_short |
New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp. |
| title_full |
New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp. |
| title_fullStr |
New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp. |
| title_full_unstemmed |
New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp. |
| title_sort |
new anti-inflammatory 9,11-secosterols with a rare tricyclo[5,2,1,1]decane ring from a formosan gorgonian pinnigorgia sp. |
| publisher |
MDPI AG |
| series |
Marine Drugs |
| issn |
1660-3397 |
| publishDate |
2016-11-01 |
| description |
Pinnigorgiols D (1) and E (2), two new 9,11-secosterols with a rearranged carbon skeleton, were isolated from a Taiwan gorgonian Pinnigorgia sp. The structures of these two compounds were elucidated on the basis of spectroscopic methods and were proven to possess a tricyclo[5,2,1,1]decane ring. The new secosterols 1 and 2 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils. |
| topic |
9,11-secosterol gorgonian Pinnigorgia anti-inflammatory superoxide anion elastase |
| url |
http://www.mdpi.com/1660-3397/14/12/218 |
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