Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation
Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer...
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doaj-781663e87dda4bca9410223f048336bd2020-11-24T22:47:16ZengMDPI AGMolecules1420-30492014-02-011922469248010.3390/molecules19022469molecules19022469Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological EvaluationPeng Wang0Hui-Hui Yuan1Xue Zhang2Yun-Ping Li3Lu-Qing Shang4Zheng Yin5College of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, ChinaCollege of Life Sciences, Nankai University, Tianjin 300071, ChinaCollege of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, ChinaCollege of Life Sciences, Nankai University, Tianjin 300071, ChinaCollege of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, ChinaCollege of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, ChinaLycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed.http://www.mdpi.com/1420-3049/19/2/2469lycorine derivativesanticancersynthesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Peng Wang Hui-Hui Yuan Xue Zhang Yun-Ping Li Lu-Qing Shang Zheng Yin |
spellingShingle |
Peng Wang Hui-Hui Yuan Xue Zhang Yun-Ping Li Lu-Qing Shang Zheng Yin Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation Molecules lycorine derivatives anticancer synthesis |
author_facet |
Peng Wang Hui-Hui Yuan Xue Zhang Yun-Ping Li Lu-Qing Shang Zheng Yin |
author_sort |
Peng Wang |
title |
Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation |
title_short |
Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation |
title_full |
Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation |
title_fullStr |
Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation |
title_full_unstemmed |
Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation |
title_sort |
novel lycorine derivatives as anticancer agents: synthesis and in vitro biological evaluation |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2014-02-01 |
description |
Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed. |
topic |
lycorine derivatives anticancer synthesis |
url |
http://www.mdpi.com/1420-3049/19/2/2469 |
work_keys_str_mv |
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