Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation

Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation

Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer...

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Main Authors: Peng Wang, Hui-Hui Yuan, Xue Zhang, Yun-Ping Li, Lu-Qing Shang, Zheng Yin
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:Molecules
Subjects:
lycorine derivatives
anticancer
synthesis
Online Access:http://www.mdpi.com/1420-3049/19/2/2469
id doaj-781663e87dda4bca9410223f048336bd
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spelling doaj-781663e87dda4bca9410223f048336bd2020-11-24T22:47:16ZengMDPI AGMolecules1420-30492014-02-011922469248010.3390/molecules19022469molecules19022469Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological EvaluationPeng Wang0Hui-Hui Yuan1Xue Zhang2Yun-Ping Li3Lu-Qing Shang4Zheng Yin5College of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, ChinaCollege of Life Sciences, Nankai University, Tianjin 300071, ChinaCollege of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, ChinaCollege of Life Sciences, Nankai University, Tianjin 300071, ChinaCollege of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, ChinaCollege of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, ChinaLycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed.http://www.mdpi.com/1420-3049/19/2/2469lycorine derivativesanticancersynthesis
collection DOAJ
language English
format Article
sources DOAJ
author Peng Wang
Hui-Hui Yuan
Xue Zhang
Yun-Ping Li
Lu-Qing Shang
Zheng Yin
spellingShingle Peng Wang
Hui-Hui Yuan
Xue Zhang
Yun-Ping Li
Lu-Qing Shang
Zheng Yin
Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation
Molecules
lycorine derivatives
anticancer
synthesis
author_facet Peng Wang
Hui-Hui Yuan
Xue Zhang
Yun-Ping Li
Lu-Qing Shang
Zheng Yin
author_sort Peng Wang
title Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation
title_short Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation
title_full Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation
title_fullStr Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation
title_full_unstemmed Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation
title_sort novel lycorine derivatives as anticancer agents: synthesis and in vitro biological evaluation
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2014-02-01
description Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed.
topic lycorine derivatives
anticancer
synthesis
url http://www.mdpi.com/1420-3049/19/2/2469
work_keys_str_mv AT pengwang novellycorinederivativesasanticanceragentssynthesisandinvitrobiologicalevaluation
AT huihuiyuan novellycorinederivativesasanticanceragentssynthesisandinvitrobiologicalevaluation
AT xuezhang novellycorinederivativesasanticanceragentssynthesisandinvitrobiologicalevaluation
AT yunpingli novellycorinederivativesasanticanceragentssynthesisandinvitrobiologicalevaluation
AT luqingshang novellycorinederivativesasanticanceragentssynthesisandinvitrobiologicalevaluation
AT zhengyin novellycorinederivativesasanticanceragentssynthesisandinvitrobiologicalevaluation
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