Interactions between Innate Lymphoid Cells and Cells of the Innate and Adaptive Immune System

Interactions between Innate Lymphoid Cells and Cells of the Innate and Adaptive Immune System

Type 2 innate lymphoid cells (ILC2s) are a major source of cytokines, which are also produced by Th2 cells and several cell types of the innate immune system. Work over the past few years indicates that ILC2s play a central role in regulating type 2 immune responses against allergens and helminths....

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Main Authors: Cornelia Symowski, David Voehringer
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
allergic inflammation
helminths
mast cells
innate lymphoid cells
eosinophils
basophils
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01422/full
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spelling doaj-781957909b464c4498b82f85bf0f7b1e2020-11-24T22:16:34ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-10-01810.3389/fimmu.2017.01422298721Interactions between Innate Lymphoid Cells and Cells of the Innate and Adaptive Immune SystemCornelia Symowski0David Voehringer1Department of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU), Erlangen, GermanyDepartment of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU), Erlangen, GermanyType 2 innate lymphoid cells (ILC2s) are a major source of cytokines, which are also produced by Th2 cells and several cell types of the innate immune system. Work over the past few years indicates that ILC2s play a central role in regulating type 2 immune responses against allergens and helminths. ILC2s can interact with a variety of cells types of the innate and adaptive immune system by cell–cell contacts or by communication via soluble factors. In this review, we provide an overview about recent advances in our understanding how ILC2s orchestrate type 2 immune responses with focus on direct interactions between ILC2s and other cells of the immune system.http://journal.frontiersin.org/article/10.3389/fimmu.2017.01422/fullallergic inflammationhelminthsmast cellsinnate lymphoid cellseosinophilsbasophils
collection DOAJ
language English
format Article
sources DOAJ
author Cornelia Symowski
David Voehringer
spellingShingle Cornelia Symowski
David Voehringer
Interactions between Innate Lymphoid Cells and Cells of the Innate and Adaptive Immune System
Frontiers in Immunology
allergic inflammation
helminths
mast cells
innate lymphoid cells
eosinophils
basophils
author_facet Cornelia Symowski
David Voehringer
author_sort Cornelia Symowski
title Interactions between Innate Lymphoid Cells and Cells of the Innate and Adaptive Immune System
title_short Interactions between Innate Lymphoid Cells and Cells of the Innate and Adaptive Immune System
title_full Interactions between Innate Lymphoid Cells and Cells of the Innate and Adaptive Immune System
title_fullStr Interactions between Innate Lymphoid Cells and Cells of the Innate and Adaptive Immune System
title_full_unstemmed Interactions between Innate Lymphoid Cells and Cells of the Innate and Adaptive Immune System
title_sort interactions between innate lymphoid cells and cells of the innate and adaptive immune system
publisher Frontiers Media S.A.
series Frontiers in Immunology
issn 1664-3224
publishDate 2017-10-01
description Type 2 innate lymphoid cells (ILC2s) are a major source of cytokines, which are also produced by Th2 cells and several cell types of the innate immune system. Work over the past few years indicates that ILC2s play a central role in regulating type 2 immune responses against allergens and helminths. ILC2s can interact with a variety of cells types of the innate and adaptive immune system by cell–cell contacts or by communication via soluble factors. In this review, we provide an overview about recent advances in our understanding how ILC2s orchestrate type 2 immune responses with focus on direct interactions between ILC2s and other cells of the immune system.
topic allergic inflammation
helminths
mast cells
innate lymphoid cells
eosinophils
basophils
url http://journal.frontiersin.org/article/10.3389/fimmu.2017.01422/full
work_keys_str_mv AT corneliasymowski interactionsbetweeninnatelymphoidcellsandcellsoftheinnateandadaptiveimmunesystem
AT davidvoehringer interactionsbetweeninnatelymphoidcellsandcellsoftheinnateandadaptiveimmunesystem
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