A bioinspired scaffold for rapid oxygenation of cell encapsulation systems
Cell encapsulation into biomaterials for transplantation is currently limited by inadequate oxygenation. Here the authors present a biomimetic scaffold featuring internal continuous air channels endowed with 10,000-fold higher O2 diffusivity than hydrogels and demonstrate correction of diabetes in i...
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Nature Publishing Group
2021-10-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-26126-w |
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doaj-781e0ecf93d24a7bb9d71476198c95102021-10-10T11:44:39ZengNature Publishing GroupNature Communications2041-17232021-10-0112111610.1038/s41467-021-26126-wA bioinspired scaffold for rapid oxygenation of cell encapsulation systemsLong-Hai Wang0Alexander Ulrich Ernst1Duo An2Ashim Kumar Datta3Boris Epel4Mrignayani Kotecha5Minglin Ma6Biological and Environmental Engineering, Cornell UniversityBiological and Environmental Engineering, Cornell UniversityBiological and Environmental Engineering, Cornell UniversityBiological and Environmental Engineering, Cornell UniversityDepartment of Radiation and Cellular Oncology, The University of ChicagoO2M Technologies, LLCBiological and Environmental Engineering, Cornell UniversityCell encapsulation into biomaterials for transplantation is currently limited by inadequate oxygenation. Here the authors present a biomimetic scaffold featuring internal continuous air channels endowed with 10,000-fold higher O2 diffusivity than hydrogels and demonstrate correction of diabetes in immunocompetent mice using rat islets for over 6 months.https://doi.org/10.1038/s41467-021-26126-w |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Long-Hai Wang Alexander Ulrich Ernst Duo An Ashim Kumar Datta Boris Epel Mrignayani Kotecha Minglin Ma |
spellingShingle |
Long-Hai Wang Alexander Ulrich Ernst Duo An Ashim Kumar Datta Boris Epel Mrignayani Kotecha Minglin Ma A bioinspired scaffold for rapid oxygenation of cell encapsulation systems Nature Communications |
author_facet |
Long-Hai Wang Alexander Ulrich Ernst Duo An Ashim Kumar Datta Boris Epel Mrignayani Kotecha Minglin Ma |
author_sort |
Long-Hai Wang |
title |
A bioinspired scaffold for rapid oxygenation of cell encapsulation systems |
title_short |
A bioinspired scaffold for rapid oxygenation of cell encapsulation systems |
title_full |
A bioinspired scaffold for rapid oxygenation of cell encapsulation systems |
title_fullStr |
A bioinspired scaffold for rapid oxygenation of cell encapsulation systems |
title_full_unstemmed |
A bioinspired scaffold for rapid oxygenation of cell encapsulation systems |
title_sort |
bioinspired scaffold for rapid oxygenation of cell encapsulation systems |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2021-10-01 |
description |
Cell encapsulation into biomaterials for transplantation is currently limited by inadequate oxygenation. Here the authors present a biomimetic scaffold featuring internal continuous air channels endowed with 10,000-fold higher O2 diffusivity than hydrogels and demonstrate correction of diabetes in immunocompetent mice using rat islets for over 6 months. |
url |
https://doi.org/10.1038/s41467-021-26126-w |
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