A bioinspired scaffold for rapid oxygenation of cell encapsulation systems

A bioinspired scaffold for rapid oxygenation of cell encapsulation systems

Cell encapsulation into biomaterials for transplantation is currently limited by inadequate oxygenation. Here the authors present a biomimetic scaffold featuring internal continuous air channels endowed with 10,000-fold higher O2 diffusivity than hydrogels and demonstrate correction of diabetes in i...

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Main Authors: Long-Hai Wang, Alexander Ulrich Ernst, Duo An, Ashim Kumar Datta, Boris Epel, Mrignayani Kotecha, Minglin Ma
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26126-w
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spelling doaj-781e0ecf93d24a7bb9d71476198c95102021-10-10T11:44:39ZengNature Publishing GroupNature Communications2041-17232021-10-0112111610.1038/s41467-021-26126-wA bioinspired scaffold for rapid oxygenation of cell encapsulation systemsLong-Hai Wang0Alexander Ulrich Ernst1Duo An2Ashim Kumar Datta3Boris Epel4Mrignayani Kotecha5Minglin Ma6Biological and Environmental Engineering, Cornell UniversityBiological and Environmental Engineering, Cornell UniversityBiological and Environmental Engineering, Cornell UniversityBiological and Environmental Engineering, Cornell UniversityDepartment of Radiation and Cellular Oncology, The University of ChicagoO2M Technologies, LLCBiological and Environmental Engineering, Cornell UniversityCell encapsulation into biomaterials for transplantation is currently limited by inadequate oxygenation. Here the authors present a biomimetic scaffold featuring internal continuous air channels endowed with 10,000-fold higher O2 diffusivity than hydrogels and demonstrate correction of diabetes in immunocompetent mice using rat islets for over 6 months.https://doi.org/10.1038/s41467-021-26126-w
collection DOAJ
language English
format Article
sources DOAJ
author Long-Hai Wang
Alexander Ulrich Ernst
Duo An
Ashim Kumar Datta
Boris Epel
Mrignayani Kotecha
Minglin Ma
spellingShingle Long-Hai Wang
Alexander Ulrich Ernst
Duo An
Ashim Kumar Datta
Boris Epel
Mrignayani Kotecha
Minglin Ma
A bioinspired scaffold for rapid oxygenation of cell encapsulation systems
Nature Communications
author_facet Long-Hai Wang
Alexander Ulrich Ernst
Duo An
Ashim Kumar Datta
Boris Epel
Mrignayani Kotecha
Minglin Ma
author_sort Long-Hai Wang
title A bioinspired scaffold for rapid oxygenation of cell encapsulation systems
title_short A bioinspired scaffold for rapid oxygenation of cell encapsulation systems
title_full A bioinspired scaffold for rapid oxygenation of cell encapsulation systems
title_fullStr A bioinspired scaffold for rapid oxygenation of cell encapsulation systems
title_full_unstemmed A bioinspired scaffold for rapid oxygenation of cell encapsulation systems
title_sort bioinspired scaffold for rapid oxygenation of cell encapsulation systems
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-10-01
description Cell encapsulation into biomaterials for transplantation is currently limited by inadequate oxygenation. Here the authors present a biomimetic scaffold featuring internal continuous air channels endowed with 10,000-fold higher O2 diffusivity than hydrogels and demonstrate correction of diabetes in immunocompetent mice using rat islets for over 6 months.
url https://doi.org/10.1038/s41467-021-26126-w
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