Effects of tadalafil on urinary continence recovery after nerve-sparing robot-assisted radical prostatectomy

• Main Authors: AV Govorov, DY Pushkar, AO Vasilyev, DV Priymak
• Format: Article
• Language: Russian
• Published: Remedium Group LLC 2014-12-01
• Series: Медицинский совет
• Subjects: ингибиторы фдэ5; симптомы нижних мочевых путей; эректильная дисфункция; билатеральная нервосберегающая роботизированная радикальная про-статэктомия; тадалафил; pde5 inhibitors; lower urinary tract symptoms; erectile dysfunction; bilateral nerve-sparing robotic radical prostatectomy; tadalafil
• Online Access: https://www.med-sovet.pro/jour/article/view/811
• ISSN: 2079-701X; 2658-5790

Phosphodiesterase type 5 (PDE5) inhibitors modulate afferent nerve activity, increase nitric oxide activity resulting in the corpus cavernosal smooth muscle relaxation in the penis, prostate, urethra and bladder neck. According the European Urological Association guidelines, PDE5 inhibitors reduce the severity of moderate to severe symptoms of impaired urination in men with and without erectile dysfunction (ED). An overview of recent literature on the use of PDE5 inhibitors showed that they can be used clinically in the treatment of erectile dysfunction as well as in the therapy of lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia and in patients with LUTS after radical prostatectomy. The aim of our study was to evaluate the role of tadalafil in restoring continence in patients after bilateral nerve-sparing robotic radical prostatectomy (bilateral NSRRPE).