Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups

The presentation of systemic lupus erythematosus has been known to differ by ancestry, but the underlying genetic factors remain unclear. Here, the authors report ancestry-specific susceptibility loci and better risk prediction when using data from matched ancestral groups.

Bibliographic Details
Main Authors:	Yong-Fei Wang, Yan Zhang, Zhiming Lin, Huoru Zhang, Ting-You Wang, Yujie Cao, David L. Morris, Yujun Sheng, Xianyong Yin, Shi-Long Zhong, Xiaoqiong Gu, Yao Lei, Jing He, Qi Wu, Jiangshan Jane Shen, Jing Yang, Tai-Hing Lam, Jia-Huang Lin, Zhi-Ming Mai, Mengbiao Guo, Yuanjia Tang, Yanhui Chen, Qin Song, Bo Ban, Chi Chiu Mok, Yong Cui, Liangjing Lu, Nan Shen, Pak C. Sham, Chak Sing Lau, David K. Smith, Timothy J. Vyse, Xuejun Zhang, Yu Lung Lau, Wanling Yang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-21049-y

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spelling	doaj-783362c0f8c8422595f0ff721e5c39ef2021-02-07T12:13:08ZengNature Publishing GroupNature Communications2041-17232021-02-0112111310.1038/s41467-021-21049-yIdentification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groupsYong-Fei Wang0Yan Zhang1Zhiming Lin2Huoru Zhang3Ting-You Wang4Yujie Cao5David L. Morris6Yujun Sheng7Xianyong Yin8Shi-Long Zhong9Xiaoqiong Gu10Yao Lei11Jing He12Qi Wu13Jiangshan Jane Shen14Jing Yang15Tai-Hing Lam16Jia-Huang Lin17Zhi-Ming Mai18Mengbiao Guo19Yuanjia Tang20Yanhui Chen21Qin Song22Bo Ban23Chi Chiu Mok24Yong Cui25Liangjing Lu26Nan Shen27Pak C. Sham28Chak Sing Lau29David K. Smith30Timothy J. Vyse31Xuejun Zhang32Yu Lung Lau33Wanling Yang34Department of Paediatrics and Adolescent Medicine, The University of Hong KongDepartment of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityDepartment of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Paediatrics and Adolescent Medicine, The University of Hong KongDepartment of Paediatrics and Adolescent Medicine, The University of Hong KongDepartment of Paediatrics and Adolescent Medicine, The University of Hong KongDivision of Genetics and Molecular Medicine, King’s College LondonDepartment of Dermatology, No.1 Hospital, Anhui Medical UniversityDepartment of Dermatology, No.1 Hospital, Anhui Medical UniversityGuangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People’s HospitalDepartment of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical CenterDepartment of Paediatrics and Adolescent Medicine, The University of Hong KongDepartment of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityDepartment of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityDepartment of Paediatrics and Adolescent Medicine, The University of Hong KongDepartment of Paediatrics and Adolescent Medicine, The University of Hong KongSchool of Public Health, The University of Hong KongSchool of Public Health, The University of Hong KongSchool of Public Health, The University of Hong KongDepartment of Paediatrics and Adolescent Medicine, The University of Hong KongShanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Pediatrics, Union Hospital Affiliated to Fujian Medical UniversityDepartment of Rheumatology, Affiliated Hospital of Jining Medical UniversityDepartment of Endocrinology, Affiliated Hospital of Jining Medical UniversityDepartment of Medicine, Tuen Mun HospitalDepartment of Dermatology, China-Japan Friendship HospitalShanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of MedicineShanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Psychiatry, The University of Hong KongDepartment of Medicine, The University of Hong KongSchool of Public Health, The University of Hong KongDivision of Genetics and Molecular Medicine, King’s College LondonDepartment of Dermatology, No.1 Hospital, Anhui Medical UniversityDepartment of Paediatrics and Adolescent Medicine, The University of Hong KongDepartment of Paediatrics and Adolescent Medicine, The University of Hong KongThe presentation of systemic lupus erythematosus has been known to differ by ancestry, but the underlying genetic factors remain unclear. Here, the authors report ancestry-specific susceptibility loci and better risk prediction when using data from matched ancestral groups.https://doi.org/10.1038/s41467-021-21049-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yong-Fei Wang Yan Zhang Zhiming Lin Huoru Zhang Ting-You Wang Yujie Cao David L. Morris Yujun Sheng Xianyong Yin Shi-Long Zhong Xiaoqiong Gu Yao Lei Jing He Qi Wu Jiangshan Jane Shen Jing Yang Tai-Hing Lam Jia-Huang Lin Zhi-Ming Mai Mengbiao Guo Yuanjia Tang Yanhui Chen Qin Song Bo Ban Chi Chiu Mok Yong Cui Liangjing Lu Nan Shen Pak C. Sham Chak Sing Lau David K. Smith Timothy J. Vyse Xuejun Zhang Yu Lung Lau Wanling Yang
spellingShingle	Yong-Fei Wang Yan Zhang Zhiming Lin Huoru Zhang Ting-You Wang Yujie Cao David L. Morris Yujun Sheng Xianyong Yin Shi-Long Zhong Xiaoqiong Gu Yao Lei Jing He Qi Wu Jiangshan Jane Shen Jing Yang Tai-Hing Lam Jia-Huang Lin Zhi-Ming Mai Mengbiao Guo Yuanjia Tang Yanhui Chen Qin Song Bo Ban Chi Chiu Mok Yong Cui Liangjing Lu Nan Shen Pak C. Sham Chak Sing Lau David K. Smith Timothy J. Vyse Xuejun Zhang Yu Lung Lau Wanling Yang Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups Nature Communications
author_facet	Yong-Fei Wang Yan Zhang Zhiming Lin Huoru Zhang Ting-You Wang Yujie Cao David L. Morris Yujun Sheng Xianyong Yin Shi-Long Zhong Xiaoqiong Gu Yao Lei Jing He Qi Wu Jiangshan Jane Shen Jing Yang Tai-Hing Lam Jia-Huang Lin Zhi-Ming Mai Mengbiao Guo Yuanjia Tang Yanhui Chen Qin Song Bo Ban Chi Chiu Mok Yong Cui Liangjing Lu Nan Shen Pak C. Sham Chak Sing Lau David K. Smith Timothy J. Vyse Xuejun Zhang Yu Lung Lau Wanling Yang
author_sort	Yong-Fei Wang
title	Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups
title_short	Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups
title_full	Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups
title_fullStr	Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups
title_full_unstemmed	Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups
title_sort	identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-02-01
description	The presentation of systemic lupus erythematosus has been known to differ by ancestry, but the underlying genetic factors remain unclear. Here, the authors report ancestry-specific susceptibility loci and better risk prediction when using data from matched ancestral groups.
url	https://doi.org/10.1038/s41467-021-21049-y
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Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups

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