The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes

The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes

Abstract Background C3H mice have been frequently used in cancer studies as animal models of spontaneous liver tumors and chemically induced hepatocellular carcinoma (HCC). Epigenetic modifications, including DNA methylation, are among pivotal control mechanisms of gene expression leading to carcino...

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Bibliographic Details
Main Authors: Junya Matsushita, Kazuyuki Okamura, Kazuhiko Nakabayashi, Takehiro Suzuki, Yu Horibe, Tomoko Kawai, Toshihiro Sakurai, Satoshi Yamashita, Yoshikazu Higami, Gaku Ichihara, Kenichiro Hata, Keiko Nohara
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Cancer
Subjects:
C3H mice
DNA methylation
Liver tumors
Reduced representation bisulfite sequencing (RRBS)
5-aza-2'-deoxycytidine
Online Access:http://link.springer.com/article/10.1186/s12885-018-4221-0

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http://link.springer.com/article/10.1186/s12885-018-4221-0

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