Risperidone-induced reversible neutropenia

• Main Authors: Kattalai Kailasam V, Chima V, Nnamdi U, Sharma K, Shah K
• Format: Article
• Language: English
• Published: Dove Medical Press 2017-07-01
• Series: Neuropsychiatric Disease and Treatment
• Subjects: risperidone; anti-psychotics; neutropenia; blood dyscrasias
• Online Access: https://www.dovepress.com/risperidone-induced-reversible-neutropenia-peer-reviewed-article-NDT
• ISSN: 1178-2021

Vasanth Kattalai Kailasam,1 Victoria Chima,2,* Uchechukwu Nnamdi,3,* Kavita Sharma,4,* Kairav Shah5 1College of Medicine, University of Illinois, Chicago, IL, USA; 2Mount Sinai Beth Israel Medical Center, New York, NY, USA; 3Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA; 4Harlem Hospital Center, New York, NY, USA; 5Department of Psychiatry & Behavioral Sciences, The University of Texas McGovern Medical School, Houston, TX, USA *These authors contributed equally to this work Abstract: This case report presents a 44-year-old man with a history of schizophrenia who developed neutropenia on risperidone therapy. The patient’s laboratory reports showed a gradual decline of leukocytes and neutrophils after resolution and rechallenging. This was reversed with the discontinuation of risperidone and by switching to olanzapine. In this case report, we also discuss the updated evidence base for management of risperidone-induced neutropenia. Keywords: risperidone, antipsychotics, neutropenia, blood dyscrasias