Serum Level of a Soluble Form of Endoglin (CD105) is Decreased after Goeckerman’s Therapy of Psoriasis

Background. Goeckerman’s therapy (GT) of psoriasis is based on daily application of pharmacy grade coal tar on affected skin with subsequent exposure to UV light. Disturbances in angiogenic activity are characteristic for the immunopathogenesis of psoriasis. The aim of study was to evaluate the infl...

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Main Authors: David Pohl, Ctirad Andrýs, Lenka Borská, Zdeněk Fiala, Květa Hamáková, Karel Ettler, Jan Krejsek
Format: Article
Language:English
Published: Karolinum Press 2011-01-01
Series:Acta Medica
Subjects:
Online Access:https://actamedica.lfhk.cuni.cz/54/2/0059/
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spelling doaj-7850745516704a7e923f77d7107260802020-11-24T22:35:55ZengKarolinum PressActa Medica1211-42861805-96942011-01-01542596210.14712/18059694.2016.19Serum Level of a Soluble Form of Endoglin (CD105) is Decreased after Goeckerman’s Therapy of PsoriasisDavid Pohl0Ctirad Andrýs1Lenka Borská2Zdeněk Fiala3Květa Hamáková4Karel Ettler5Jan Krejsek6Charles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Clinical Immunology and Allergy, Czech RepublicCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Clinical Immunology and Allergy, Czech RepublicCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Pathological Physiology, Czech RepublicCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Hygiene and Preventive Medicine, Czech RepublicCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Dermatology and Venereology, Czech RepublicCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Dermatology and Venereology, Czech RepublicCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Clinical Immunology and Allergy, Czech RepublicBackground. Goeckerman’s therapy (GT) of psoriasis is based on daily application of pharmacy grade coal tar on affected skin with subsequent exposure to UV light. Disturbances in angiogenic activity are characteristic for the immunopathogenesis of psoriasis. The aim of study was to evaluate the influence of GT of psoriasis on proinflammatory and angiogenic activities expressed as changes in levels of endoglin (CD105). Methods. Serum levels of a soluble form of endoglin were measured in peripheral blood samples of 38 patients with psoriasis before and after therapy. Sixty three otherwise healthy blood donors serve as a control group. The efficacy of GT was expressed as changes in Psoriasis Area and Severity Index (PASI). Results. PASI score was significantly diminished by GT (p<0.001). Serum levels of soluble CD105 were significantly diminished after GT. The serum level of soluble CD105 dropped from 7.85 ± 2.26 ng/ml before therapy to 7.01 ± 1.71 ng/ml after therapy (p= 0.0002). Compared to serum levels of soluble CD105 in healthy blood donors, serum levels of soluble CD105 in patients before GT were significantly higher (p<0.001) and remained elevated after therapy (p<0.001). Angiogenic activity expressed as serum endoglin is diminished in patients with psoriasis treated by GT.https://actamedica.lfhk.cuni.cz/54/2/0059/PsoriasisGoeckerman’s therapyAngiogenesisEndoglinCD105
collection DOAJ
language English
format Article
sources DOAJ
author David Pohl
Ctirad Andrýs
Lenka Borská
Zdeněk Fiala
Květa Hamáková
Karel Ettler
Jan Krejsek
spellingShingle David Pohl
Ctirad Andrýs
Lenka Borská
Zdeněk Fiala
Květa Hamáková
Karel Ettler
Jan Krejsek
Serum Level of a Soluble Form of Endoglin (CD105) is Decreased after Goeckerman’s Therapy of Psoriasis
Acta Medica
Psoriasis
Goeckerman’s therapy
Angiogenesis
Endoglin
CD105
author_facet David Pohl
Ctirad Andrýs
Lenka Borská
Zdeněk Fiala
Květa Hamáková
Karel Ettler
Jan Krejsek
author_sort David Pohl
title Serum Level of a Soluble Form of Endoglin (CD105) is Decreased after Goeckerman’s Therapy of Psoriasis
title_short Serum Level of a Soluble Form of Endoglin (CD105) is Decreased after Goeckerman’s Therapy of Psoriasis
title_full Serum Level of a Soluble Form of Endoglin (CD105) is Decreased after Goeckerman’s Therapy of Psoriasis
title_fullStr Serum Level of a Soluble Form of Endoglin (CD105) is Decreased after Goeckerman’s Therapy of Psoriasis
title_full_unstemmed Serum Level of a Soluble Form of Endoglin (CD105) is Decreased after Goeckerman’s Therapy of Psoriasis
title_sort serum level of a soluble form of endoglin (cd105) is decreased after goeckerman’s therapy of psoriasis
publisher Karolinum Press
series Acta Medica
issn 1211-4286
1805-9694
publishDate 2011-01-01
description Background. Goeckerman’s therapy (GT) of psoriasis is based on daily application of pharmacy grade coal tar on affected skin with subsequent exposure to UV light. Disturbances in angiogenic activity are characteristic for the immunopathogenesis of psoriasis. The aim of study was to evaluate the influence of GT of psoriasis on proinflammatory and angiogenic activities expressed as changes in levels of endoglin (CD105). Methods. Serum levels of a soluble form of endoglin were measured in peripheral blood samples of 38 patients with psoriasis before and after therapy. Sixty three otherwise healthy blood donors serve as a control group. The efficacy of GT was expressed as changes in Psoriasis Area and Severity Index (PASI). Results. PASI score was significantly diminished by GT (p<0.001). Serum levels of soluble CD105 were significantly diminished after GT. The serum level of soluble CD105 dropped from 7.85 ± 2.26 ng/ml before therapy to 7.01 ± 1.71 ng/ml after therapy (p= 0.0002). Compared to serum levels of soluble CD105 in healthy blood donors, serum levels of soluble CD105 in patients before GT were significantly higher (p<0.001) and remained elevated after therapy (p<0.001). Angiogenic activity expressed as serum endoglin is diminished in patients with psoriasis treated by GT.
topic Psoriasis
Goeckerman’s therapy
Angiogenesis
Endoglin
CD105
url https://actamedica.lfhk.cuni.cz/54/2/0059/
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