Moderate High Caloric Maternal Diet Impacts Dam Breast Milk Metabotype and Offspring Lipidome in a Sex-Specific Manner
Lactation is a critical period during which maternal sub- or over-nutrition affect milk composition and offspring development that can have lasting health effects. The consequences of moderate high-fat, high-simple carbohydrate diet (WD) consumption by rat dams, during gestation and lactation, on mi...
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doaj-7860c3e5b8a34ac992396e29c06718d12020-11-25T03:48:25ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-01215428542810.3390/ijms21155428Moderate High Caloric Maternal Diet Impacts Dam Breast Milk Metabotype and Offspring Lipidome in a Sex-Specific MannerMarie-Cécile Alexandre-Gouabau0Agnès David-Sochard1Anne-Lise Royer2Patricia Parnet3Vincent Paillé4Unité Mixte de Recherche 1280, Laboratoire de Physiopathologie des Adaptations Nutritionnelles, Institut National de la Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAe), LUNAM Université, Centre Hospitalier Universitaire Hôtel-Dieu, Place Alexis Ricordeau, HNB1, 44093 Nantes CEDEX 1, FranceUnité Mixte de Recherche 1280, Laboratoire de Physiopathologie des Adaptations Nutritionnelles, Institut National de la Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAe), LUNAM Université, Centre Hospitalier Universitaire Hôtel-Dieu, Place Alexis Ricordeau, HNB1, 44093 Nantes CEDEX 1, FranceUSC INRA 1329, Laboratoire d’Etude des Résidus et Contaminants dans les Aliments (LABERCA), LUNAM Université, ONIRIS, F-44000 Nantes, FranceUnité Mixte de Recherche 1280, Laboratoire de Physiopathologie des Adaptations Nutritionnelles, Institut National de la Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAe), LUNAM Université, Centre Hospitalier Universitaire Hôtel-Dieu, Place Alexis Ricordeau, HNB1, 44093 Nantes CEDEX 1, FranceUnité Mixte de Recherche 1280, Laboratoire de Physiopathologie des Adaptations Nutritionnelles, Institut National de la Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAe), LUNAM Université, Centre Hospitalier Universitaire Hôtel-Dieu, Place Alexis Ricordeau, HNB1, 44093 Nantes CEDEX 1, FranceLactation is a critical period during which maternal sub- or over-nutrition affect milk composition and offspring development that can have lasting health effects. The consequences of moderate high-fat, high-simple carbohydrate diet (WD) consumption by rat dams, during gestation and lactation, on milk composition and offspring blood lipidome and its growth, at weaning, were investigated by using a comprehensive lipidomic study on mass-spectrometric platform combined to targeted fatty- and free amino-acids analysis. This holistic approach allowed clear-cut differences in mature milk-lipidomic signature according to maternal diet with a similar content of protein, lactose and leptin. The lower WD-milk content in total fat and triglycerides (TGs), particularly in TGs-with saturated medium-chain, and higher levels in both sphingolipid (SL) and TG species with unsaturated long-chain were associated to a specific offspring blood-lipidome with decreased levels in TGs-containing saturated fatty acid (FA). The sexual-dimorphism in the FA-distribution in TG (higher TGs-rich in oleic and linoleic acids, specifically in males) and SL species (increased levels in very long-chain ceramides, specifically in females) could be associated with some differences that we observed between males and females like a higher total body weight gain in females and an increased preference for fatty taste in males upon weaning.https://www.mdpi.com/1422-0067/21/15/5428DOHaDmilk phenotypinglactational programminghigh caloric challengeoffspring lipidome |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marie-Cécile Alexandre-Gouabau Agnès David-Sochard Anne-Lise Royer Patricia Parnet Vincent Paillé |
spellingShingle |
Marie-Cécile Alexandre-Gouabau Agnès David-Sochard Anne-Lise Royer Patricia Parnet Vincent Paillé Moderate High Caloric Maternal Diet Impacts Dam Breast Milk Metabotype and Offspring Lipidome in a Sex-Specific Manner International Journal of Molecular Sciences DOHaD milk phenotyping lactational programming high caloric challenge offspring lipidome |
author_facet |
Marie-Cécile Alexandre-Gouabau Agnès David-Sochard Anne-Lise Royer Patricia Parnet Vincent Paillé |
author_sort |
Marie-Cécile Alexandre-Gouabau |
title |
Moderate High Caloric Maternal Diet Impacts Dam Breast Milk Metabotype and Offspring Lipidome in a Sex-Specific Manner |
title_short |
Moderate High Caloric Maternal Diet Impacts Dam Breast Milk Metabotype and Offspring Lipidome in a Sex-Specific Manner |
title_full |
Moderate High Caloric Maternal Diet Impacts Dam Breast Milk Metabotype and Offspring Lipidome in a Sex-Specific Manner |
title_fullStr |
Moderate High Caloric Maternal Diet Impacts Dam Breast Milk Metabotype and Offspring Lipidome in a Sex-Specific Manner |
title_full_unstemmed |
Moderate High Caloric Maternal Diet Impacts Dam Breast Milk Metabotype and Offspring Lipidome in a Sex-Specific Manner |
title_sort |
moderate high caloric maternal diet impacts dam breast milk metabotype and offspring lipidome in a sex-specific manner |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-07-01 |
description |
Lactation is a critical period during which maternal sub- or over-nutrition affect milk composition and offspring development that can have lasting health effects. The consequences of moderate high-fat, high-simple carbohydrate diet (WD) consumption by rat dams, during gestation and lactation, on milk composition and offspring blood lipidome and its growth, at weaning, were investigated by using a comprehensive lipidomic study on mass-spectrometric platform combined to targeted fatty- and free amino-acids analysis. This holistic approach allowed clear-cut differences in mature milk-lipidomic signature according to maternal diet with a similar content of protein, lactose and leptin. The lower WD-milk content in total fat and triglycerides (TGs), particularly in TGs-with saturated medium-chain, and higher levels in both sphingolipid (SL) and TG species with unsaturated long-chain were associated to a specific offspring blood-lipidome with decreased levels in TGs-containing saturated fatty acid (FA). The sexual-dimorphism in the FA-distribution in TG (higher TGs-rich in oleic and linoleic acids, specifically in males) and SL species (increased levels in very long-chain ceramides, specifically in females) could be associated with some differences that we observed between males and females like a higher total body weight gain in females and an increased preference for fatty taste in males upon weaning. |
topic |
DOHaD milk phenotyping lactational programming high caloric challenge offspring lipidome |
url |
https://www.mdpi.com/1422-0067/21/15/5428 |
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