The first transmembrane region of complement component-9 acts as a brake on its self-assembly

The first transmembrane region of complement component-9 acts as a brake on its self-assembly

The Complement component 9 (C9) is the pore-forming component of the Membrane Attack Complex which targets pathogens. Here authors use structural biology to compare monomeric C9 to C9 within the polymeric assembly and identify the element which inhibits C9 self-assembly in the absence of the target...

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Main Authors: Bradley A. Spicer, Ruby H. P. Law, Tom T. Caradoc-Davies, Sue M. Ekkel, Charles Bayly-Jones, Siew-Siew Pang, Paul J. Conroy, Georg Ramm, Mazdak Radjainia, Hariprasad Venugopal, James C. Whisstock, Michelle A. Dunstone
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05717-0
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spelling doaj-786ad92e96b04d58a33f04be085b99012021-05-11T10:30:07ZengNature Publishing GroupNature Communications2041-17232018-08-01911710.1038/s41467-018-05717-0The first transmembrane region of complement component-9 acts as a brake on its self-assemblyBradley A. Spicer0Ruby H. P. Law1Tom T. Caradoc-Davies2Sue M. Ekkel3Charles Bayly-Jones4Siew-Siew Pang5Paul J. Conroy6Georg Ramm7Mazdak Radjainia8Hariprasad Venugopal9James C. Whisstock10Michelle A. Dunstone11ARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityAchtseweg Noord 5, BuildingARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityThe Complement component 9 (C9) is the pore-forming component of the Membrane Attack Complex which targets pathogens. Here authors use structural biology to compare monomeric C9 to C9 within the polymeric assembly and identify the element which inhibits C9 self-assembly in the absence of the target membrane.https://doi.org/10.1038/s41467-018-05717-0
collection DOAJ
language English
format Article
sources DOAJ
author Bradley A. Spicer
Ruby H. P. Law
Tom T. Caradoc-Davies
Sue M. Ekkel
Charles Bayly-Jones
Siew-Siew Pang
Paul J. Conroy
Georg Ramm
Mazdak Radjainia
Hariprasad Venugopal
James C. Whisstock
Michelle A. Dunstone
spellingShingle Bradley A. Spicer
Ruby H. P. Law
Tom T. Caradoc-Davies
Sue M. Ekkel
Charles Bayly-Jones
Siew-Siew Pang
Paul J. Conroy
Georg Ramm
Mazdak Radjainia
Hariprasad Venugopal
James C. Whisstock
Michelle A. Dunstone
The first transmembrane region of complement component-9 acts as a brake on its self-assembly
Nature Communications
author_facet Bradley A. Spicer
Ruby H. P. Law
Tom T. Caradoc-Davies
Sue M. Ekkel
Charles Bayly-Jones
Siew-Siew Pang
Paul J. Conroy
Georg Ramm
Mazdak Radjainia
Hariprasad Venugopal
James C. Whisstock
Michelle A. Dunstone
author_sort Bradley A. Spicer
title The first transmembrane region of complement component-9 acts as a brake on its self-assembly
title_short The first transmembrane region of complement component-9 acts as a brake on its self-assembly
title_full The first transmembrane region of complement component-9 acts as a brake on its self-assembly
title_fullStr The first transmembrane region of complement component-9 acts as a brake on its self-assembly
title_full_unstemmed The first transmembrane region of complement component-9 acts as a brake on its self-assembly
title_sort first transmembrane region of complement component-9 acts as a brake on its self-assembly
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-08-01
description The Complement component 9 (C9) is the pore-forming component of the Membrane Attack Complex which targets pathogens. Here authors use structural biology to compare monomeric C9 to C9 within the polymeric assembly and identify the element which inhibits C9 self-assembly in the absence of the target membrane.
url https://doi.org/10.1038/s41467-018-05717-0
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