The first transmembrane region of complement component-9 acts as a brake on its self-assembly
The Complement component 9 (C9) is the pore-forming component of the Membrane Attack Complex which targets pathogens. Here authors use structural biology to compare monomeric C9 to C9 within the polymeric assembly and identify the element which inhibits C9 self-assembly in the absence of the target...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-08-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-05717-0 |
id |
doaj-786ad92e96b04d58a33f04be085b9901 |
---|---|
record_format |
Article |
spelling |
doaj-786ad92e96b04d58a33f04be085b99012021-05-11T10:30:07ZengNature Publishing GroupNature Communications2041-17232018-08-01911710.1038/s41467-018-05717-0The first transmembrane region of complement component-9 acts as a brake on its self-assemblyBradley A. Spicer0Ruby H. P. Law1Tom T. Caradoc-Davies2Sue M. Ekkel3Charles Bayly-Jones4Siew-Siew Pang5Paul J. Conroy6Georg Ramm7Mazdak Radjainia8Hariprasad Venugopal9James C. Whisstock10Michelle A. Dunstone11ARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityAchtseweg Noord 5, BuildingARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityARC Centre of Excellence in Advanced Molecular Imaging, Department of Biochemistry and Molecular Biology, 23 Innovation Walk, Monash UniversityThe Complement component 9 (C9) is the pore-forming component of the Membrane Attack Complex which targets pathogens. Here authors use structural biology to compare monomeric C9 to C9 within the polymeric assembly and identify the element which inhibits C9 self-assembly in the absence of the target membrane.https://doi.org/10.1038/s41467-018-05717-0 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bradley A. Spicer Ruby H. P. Law Tom T. Caradoc-Davies Sue M. Ekkel Charles Bayly-Jones Siew-Siew Pang Paul J. Conroy Georg Ramm Mazdak Radjainia Hariprasad Venugopal James C. Whisstock Michelle A. Dunstone |
spellingShingle |
Bradley A. Spicer Ruby H. P. Law Tom T. Caradoc-Davies Sue M. Ekkel Charles Bayly-Jones Siew-Siew Pang Paul J. Conroy Georg Ramm Mazdak Radjainia Hariprasad Venugopal James C. Whisstock Michelle A. Dunstone The first transmembrane region of complement component-9 acts as a brake on its self-assembly Nature Communications |
author_facet |
Bradley A. Spicer Ruby H. P. Law Tom T. Caradoc-Davies Sue M. Ekkel Charles Bayly-Jones Siew-Siew Pang Paul J. Conroy Georg Ramm Mazdak Radjainia Hariprasad Venugopal James C. Whisstock Michelle A. Dunstone |
author_sort |
Bradley A. Spicer |
title |
The first transmembrane region of complement component-9 acts as a brake on its self-assembly |
title_short |
The first transmembrane region of complement component-9 acts as a brake on its self-assembly |
title_full |
The first transmembrane region of complement component-9 acts as a brake on its self-assembly |
title_fullStr |
The first transmembrane region of complement component-9 acts as a brake on its self-assembly |
title_full_unstemmed |
The first transmembrane region of complement component-9 acts as a brake on its self-assembly |
title_sort |
first transmembrane region of complement component-9 acts as a brake on its self-assembly |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-08-01 |
description |
The Complement component 9 (C9) is the pore-forming component of the Membrane Attack Complex which targets pathogens. Here authors use structural biology to compare monomeric C9 to C9 within the polymeric assembly and identify the element which inhibits C9 self-assembly in the absence of the target membrane. |
url |
https://doi.org/10.1038/s41467-018-05717-0 |
work_keys_str_mv |
AT bradleyaspicer thefirsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT rubyhplaw thefirsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT tomtcaradocdavies thefirsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT suemekkel thefirsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT charlesbaylyjones thefirsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT siewsiewpang thefirsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT pauljconroy thefirsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT georgramm thefirsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT mazdakradjainia thefirsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT hariprasadvenugopal thefirsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT jamescwhisstock thefirsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT michelleadunstone thefirsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT bradleyaspicer firsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT rubyhplaw firsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT tomtcaradocdavies firsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT suemekkel firsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT charlesbaylyjones firsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT siewsiewpang firsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT pauljconroy firsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT georgramm firsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT mazdakradjainia firsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT hariprasadvenugopal firsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT jamescwhisstock firsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly AT michelleadunstone firsttransmembraneregionofcomplementcomponent9actsasabrakeonitsselfassembly |
_version_ |
1721448055750787072 |