Environmental Exposure to Endocrine Disrupting Chemicals Influences Genomic Imprinting, Growth, and Metabolism
Genomic imprinting is an epigenetic mechanism that results in monoallelic, parent-of-origin-specific expression of a small number of genes. Imprinted genes play a crucial role in mammalian development as their dysregulation result in an increased risk of human diseases. DNA methylation, which underg...
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doaj-7872d4a2feb6460da33f6f6eda1ce79b2021-08-26T13:46:43ZengMDPI AGGenes2073-44252021-07-01121153115310.3390/genes12081153Environmental Exposure to Endocrine Disrupting Chemicals Influences Genomic Imprinting, Growth, and MetabolismNicole Robles-Matos0Tre Artis1Rebecca A. Simmons2Marisa S. Bartolomei3Epigenetics Institute, Center of Excellence in Environmental Toxicology, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, 9-122 Smilow Center for Translational Research, Philadelphia, PA 19104, USADivision of Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USACenter of Excellence in Environmental Toxicology, Department of Pediatrics, Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, 1308 Biomedical Research Building II/III, Philadelphia, PA 19104, USAEpigenetics Institute, Center of Excellence in Environmental Toxicology, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, 9-122 Smilow Center for Translational Research, Philadelphia, PA 19104, USAGenomic imprinting is an epigenetic mechanism that results in monoallelic, parent-of-origin-specific expression of a small number of genes. Imprinted genes play a crucial role in mammalian development as their dysregulation result in an increased risk of human diseases. DNA methylation, which undergoes dynamic changes early in development, is one of the epigenetic marks regulating imprinted gene expression patterns during early development. Thus, environmental insults, including endocrine disrupting chemicals during critical periods of fetal development, can alter DNA methylation patterns, leading to inappropriate developmental gene expression and disease risk. Here, we summarize the current literature on the impacts of in utero exposure to endocrine disrupting chemicals on genomic imprinting and metabolism in humans and rodents. We evaluate how early-life environmental exposures are a potential risk factor for adult metabolic diseases. We also introduce our mouse model of phthalate exposure. Finally, we describe the potential of genomic imprinting to serve as an environmental sensor during early development and as a novel biomarker for postnatal health outcomes.https://www.mdpi.com/2073-4425/12/8/1153endocrine disrupting chemicalsphthalatesbisphenol ApesticidesDOHaD hypothesisepigenetics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nicole Robles-Matos Tre Artis Rebecca A. Simmons Marisa S. Bartolomei |
spellingShingle |
Nicole Robles-Matos Tre Artis Rebecca A. Simmons Marisa S. Bartolomei Environmental Exposure to Endocrine Disrupting Chemicals Influences Genomic Imprinting, Growth, and Metabolism Genes endocrine disrupting chemicals phthalates bisphenol A pesticides DOHaD hypothesis epigenetics |
author_facet |
Nicole Robles-Matos Tre Artis Rebecca A. Simmons Marisa S. Bartolomei |
author_sort |
Nicole Robles-Matos |
title |
Environmental Exposure to Endocrine Disrupting Chemicals Influences Genomic Imprinting, Growth, and Metabolism |
title_short |
Environmental Exposure to Endocrine Disrupting Chemicals Influences Genomic Imprinting, Growth, and Metabolism |
title_full |
Environmental Exposure to Endocrine Disrupting Chemicals Influences Genomic Imprinting, Growth, and Metabolism |
title_fullStr |
Environmental Exposure to Endocrine Disrupting Chemicals Influences Genomic Imprinting, Growth, and Metabolism |
title_full_unstemmed |
Environmental Exposure to Endocrine Disrupting Chemicals Influences Genomic Imprinting, Growth, and Metabolism |
title_sort |
environmental exposure to endocrine disrupting chemicals influences genomic imprinting, growth, and metabolism |
publisher |
MDPI AG |
series |
Genes |
issn |
2073-4425 |
publishDate |
2021-07-01 |
description |
Genomic imprinting is an epigenetic mechanism that results in monoallelic, parent-of-origin-specific expression of a small number of genes. Imprinted genes play a crucial role in mammalian development as their dysregulation result in an increased risk of human diseases. DNA methylation, which undergoes dynamic changes early in development, is one of the epigenetic marks regulating imprinted gene expression patterns during early development. Thus, environmental insults, including endocrine disrupting chemicals during critical periods of fetal development, can alter DNA methylation patterns, leading to inappropriate developmental gene expression and disease risk. Here, we summarize the current literature on the impacts of in utero exposure to endocrine disrupting chemicals on genomic imprinting and metabolism in humans and rodents. We evaluate how early-life environmental exposures are a potential risk factor for adult metabolic diseases. We also introduce our mouse model of phthalate exposure. Finally, we describe the potential of genomic imprinting to serve as an environmental sensor during early development and as a novel biomarker for postnatal health outcomes. |
topic |
endocrine disrupting chemicals phthalates bisphenol A pesticides DOHaD hypothesis epigenetics |
url |
https://www.mdpi.com/2073-4425/12/8/1153 |
work_keys_str_mv |
AT nicoleroblesmatos environmentalexposuretoendocrinedisruptingchemicalsinfluencesgenomicimprintinggrowthandmetabolism AT treartis environmentalexposuretoendocrinedisruptingchemicalsinfluencesgenomicimprintinggrowthandmetabolism AT rebeccaasimmons environmentalexposuretoendocrinedisruptingchemicalsinfluencesgenomicimprintinggrowthandmetabolism AT marisasbartolomei environmentalexposuretoendocrinedisruptingchemicalsinfluencesgenomicimprintinggrowthandmetabolism |
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1721193155225714688 |