Activity-dependent dendritic spine shrinkage and growth involve downregulation of cofilin via distinct mechanisms.
A current model posits that cofilin-dependent actin severing negatively impacts dendritic spine volume. Studies suggested that increased cofilin activity underlies activity-dependent spine shrinkage, and that reduced cofilin activity induces activity-dependent spine growth. We suggest instead that b...
Main Authors: | Barbara Calabrese, Jean-Michel Saffin, Shelley Halpain |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3989342?pdf=render |
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