Paradigm Shift in Drug Re-purposing From Phenalenone to Phenaleno-Furanone to Combat Multi-Drug Resistant Salmonella enterica Serovar Typhi

Paradigm Shift in Drug Re-purposing From Phenalenone to Phenaleno-Furanone to Combat Multi-Drug Resistant Salmonella enterica Serovar Typhi

Over recent years, typhoid fever has gained increasing attention with several cases reporting treatment failure due to multidrug resistant (MDR) strains of Salmonella enterica serovar Typhi. While new drug development strategies are being devised to combat the threat posed by these MDR pathogens, dr...

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Bibliographic Details
Main Authors: Shama Mujawar, Derek Gatherer, Chandrajit Lahiri
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
drug repurposing
salmonellosis
multidrug resistance
chaperones
SicA
DnaK
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00402/full

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