Immunotherapy targeting glioma stem cells and its microenvironment
Glioma is the most prevailing primary malignant tumor in the central nervous system.Given that glioma stem cells (GSCs) and its microenvironment are pivotal for the occurrence and progressionof glioma, various targeted therapy including immunotherapy is promising to improve prognosis of glioma.Monoc...
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Tianjin Huanhu Hospital
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doaj-7882d8f8bf1a43bd83e8385438cd20392020-11-25T03:07:37ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312020-02-0120286952043Immunotherapy targeting glioma stem cells and its microenvironmentHai⁃yang WANGJun DONGGlioma is the most prevailing primary malignant tumor in the central nervous system.Given that glioma stem cells (GSCs) and its microenvironment are pivotal for the occurrence and progressionof glioma, various targeted therapy including immunotherapy is promising to improve prognosis of glioma.Monoclonal antibodies could inhibit GSCs biological activity through specifically recognizing GSCs markers.GSCs tumor⁃related gene mutations lead to selective replication of oncolytic viruses in GSCs, which inhibitsproliferation of GSCs. The chimeric antigen receptor T cells (CAR ⁃ T) are activated in vitro, transferredback, and set off targeted immune cascade towards GSCs. Because of the high expression of activatedligand and low expression of major histocompatibility complexⅠ (MHC⁃Ⅰ)in GSCs, Natural killer (NK)cells have a promising anti⁃tumor performance. Furthermore, the inhibition of immune checkpoints in GSCsmicroenvironment plays a vital role in process of immune escape. So intervention of these immunecheckpoints has be a heated topic in tumor immunotherapy. Although the immunotherapy strategy targetingGSCs shows a certain effect to varying degrees, it is far from mature and needs to be further explored. DOI:10.3969/j.issn.1672⁃6731.2020.02.004http://www.cjcnn.org/index.php/cjcnn/article/view/2088gliomaneoplastic stem cellstumor microenvironmentimmunotherapyreview |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hai⁃yang WANG Jun DONG |
spellingShingle |
Hai⁃yang WANG Jun DONG Immunotherapy targeting glioma stem cells and its microenvironment Chinese Journal of Contemporary Neurology and Neurosurgery glioma neoplastic stem cells tumor microenvironment immunotherapy review |
author_facet |
Hai⁃yang WANG Jun DONG |
author_sort |
Hai⁃yang WANG |
title |
Immunotherapy targeting glioma stem cells and its microenvironment |
title_short |
Immunotherapy targeting glioma stem cells and its microenvironment |
title_full |
Immunotherapy targeting glioma stem cells and its microenvironment |
title_fullStr |
Immunotherapy targeting glioma stem cells and its microenvironment |
title_full_unstemmed |
Immunotherapy targeting glioma stem cells and its microenvironment |
title_sort |
immunotherapy targeting glioma stem cells and its microenvironment |
publisher |
Tianjin Huanhu Hospital |
series |
Chinese Journal of Contemporary Neurology and Neurosurgery |
issn |
1672-6731 |
publishDate |
2020-02-01 |
description |
Glioma is the most prevailing primary malignant tumor in the central nervous system.Given that glioma stem cells (GSCs) and its microenvironment are pivotal for the occurrence and progressionof glioma, various targeted therapy including immunotherapy is promising to improve prognosis of glioma.Monoclonal antibodies could inhibit GSCs biological activity through specifically recognizing GSCs markers.GSCs tumor⁃related gene mutations lead to selective replication of oncolytic viruses in GSCs, which inhibitsproliferation of GSCs. The chimeric antigen receptor T cells (CAR ⁃ T) are activated in vitro, transferredback, and set off targeted immune cascade towards GSCs. Because of the high expression of activatedligand and low expression of major histocompatibility complexⅠ (MHC⁃Ⅰ)in GSCs, Natural killer (NK)cells have a promising anti⁃tumor performance. Furthermore, the inhibition of immune checkpoints in GSCsmicroenvironment plays a vital role in process of immune escape. So intervention of these immunecheckpoints has be a heated topic in tumor immunotherapy. Although the immunotherapy strategy targetingGSCs shows a certain effect to varying degrees, it is far from mature and needs to be further explored.
DOI:10.3969/j.issn.1672⁃6731.2020.02.004 |
topic |
glioma neoplastic stem cells tumor microenvironment immunotherapy review |
url |
http://www.cjcnn.org/index.php/cjcnn/article/view/2088 |
work_keys_str_mv |
AT haiyangwang immunotherapytargetinggliomastemcellsanditsmicroenvironment AT jundong immunotherapytargetinggliomastemcellsanditsmicroenvironment |
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