Prevalence and Fluoroquinolone Resistance Pattern in Escherichia coli Isolates of Urinary Tract Infection (UTI) Patients
Background: Urinary tract infections (UTIs) are among the most common infectious diseases all over the world. Recent studies reported an increased antibiotic resistance in Escherichia coli, primary causative agent of UTI. The resistance has emerged even to more potent antimicrobial agents like...
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doaj-7883a8ac0ddb4fdfbd05c697411ba5542020-11-25T01:16:10ZengKrishna Institute of Medical Sciences UniversityJournal of Krishna Institute of Medical Sciences University2231-42612231-42612015-04-0104025664Prevalence and Fluoroquinolone Resistance Pattern in Escherichia coli Isolates of Urinary Tract Infection (UTI) PatientsTippireddypalli Gururaju, 0Vemula Sarojamma1Vadde Ramakrishna2Department of Microbiology, Sri Venkateswara Medical College, Tirupathi–517507, (Andhra Pradesh), India,Department of Microbiology, Sri Venkateswara Medical College, Tirupathi–517507, (Andhra Pradesh), India,Department of Biotechnology & Bioinformatics, Yogi Vemana University, Kadapa – 516003 (Andhra Pradesh) IndiaBackground: Urinary tract infections (UTIs) are among the most common infectious diseases all over the world. Recent studies reported an increased antibiotic resistance in Escherichia coli, primary causative agent of UTI. The resistance has emerged even to more potent antimicrobial agents like fluoroquinolones. Objectives: The present study was undertaken to evaluate the prevalence and resistance pattern of E.coli causing UTIs in patients admitted to a tertiary care hospital in South India, with reference to fluoroquinolones. Material and Methods: A total of 278 selected urine samples of urinary tract infections were processed for E.coli culture using standard methods. For these urinary E. coli isolates, susceptibility to various antibiotics including fluoroquinolones was checked by Kirby Bauer disk diffusion method according CLSI criteria. Final resistance to fluoroquinolones isolates was analyzed. Results: Out of the 278 selected UTI clinical isolates 148 (54%) showed ciprofloxacin sensitive and 130 (46%) clinical isolates are ciprofloxacin resistant. Of the 130 ciprofloxacin resistant urinary isolates of E. coli subjected to susceptibility test for increased generation of fluoroquinolone drugs, the pattern of resistance noticed as levofloxacin (2nd generation) 79%, gatifloxacin (3rd generation) 77% and moxifloxacin (4th generation) 75%, respectively. The fluoroquinolone resistance in UTI clinical isolates was decreasing with increasing generations of fluoroquinolone. Quinolone drug resistance in clinical isolates was increasing with age and hospitalized patients. Conclusion: Study showed an increased fluoroquinolone resistance among uropathogenic E. coli isolates of UTI. These increased antibiotic resistance trends in UTI patients indicated that it is imperative to rationalize the use of antimicrobials and to use them conservatively.http://jkimsu.com/jkimsu-vol4no2/JKIMSU,Vol.4,No.2,April-June2015Page56-64.pdfUrinary tract infectionsEscherichia coliAntibiotic sensitivityFluoroquinolones |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tippireddypalli Gururaju, Vemula Sarojamma Vadde Ramakrishna |
spellingShingle |
Tippireddypalli Gururaju, Vemula Sarojamma Vadde Ramakrishna Prevalence and Fluoroquinolone Resistance Pattern in Escherichia coli Isolates of Urinary Tract Infection (UTI) Patients Journal of Krishna Institute of Medical Sciences University Urinary tract infections Escherichia coli Antibiotic sensitivity Fluoroquinolones |
author_facet |
Tippireddypalli Gururaju, Vemula Sarojamma Vadde Ramakrishna |
author_sort |
Tippireddypalli Gururaju, |
title |
Prevalence and Fluoroquinolone Resistance Pattern in Escherichia coli Isolates of Urinary Tract Infection (UTI) Patients |
title_short |
Prevalence and Fluoroquinolone Resistance Pattern in Escherichia coli Isolates of Urinary Tract Infection (UTI) Patients |
title_full |
Prevalence and Fluoroquinolone Resistance Pattern in Escherichia coli Isolates of Urinary Tract Infection (UTI) Patients |
title_fullStr |
Prevalence and Fluoroquinolone Resistance Pattern in Escherichia coli Isolates of Urinary Tract Infection (UTI) Patients |
title_full_unstemmed |
Prevalence and Fluoroquinolone Resistance Pattern in Escherichia coli Isolates of Urinary Tract Infection (UTI) Patients |
title_sort |
prevalence and fluoroquinolone resistance pattern in escherichia coli isolates of urinary tract infection (uti) patients |
publisher |
Krishna Institute of Medical Sciences University |
series |
Journal of Krishna Institute of Medical Sciences University |
issn |
2231-4261 2231-4261 |
publishDate |
2015-04-01 |
description |
Background: Urinary tract infections (UTIs) are
among the most common infectious diseases all
over the world. Recent studies reported an increased
antibiotic resistance in Escherichia coli, primary
causative agent of UTI. The resistance has emerged
even to more potent antimicrobial agents like
fluoroquinolones. Objectives: The present study
was undertaken to evaluate the prevalence and
resistance pattern of E.coli causing UTIs in patients
admitted to a tertiary care hospital in South India,
with reference to fluoroquinolones. Material and
Methods: A total of 278 selected urine samples of
urinary tract infections were processed for E.coli
culture using standard methods. For these urinary
E. coli isolates, susceptibility to various antibiotics
including fluoroquinolones was checked by Kirby
Bauer disk diffusion method according CLSI criteria.
Final resistance to fluoroquinolones isolates was
analyzed. Results: Out of the 278 selected UTI clinical
isolates 148 (54%) showed ciprofloxacin sensitive
and 130 (46%) clinical isolates are ciprofloxacin
resistant. Of the 130 ciprofloxacin resistant urinary
isolates of E. coli subjected to susceptibility test
for increased generation of fluoroquinolone drugs,
the pattern of resistance noticed as levofloxacin (2nd
generation) 79%, gatifloxacin (3rd generation) 77%
and moxifloxacin (4th generation) 75%, respectively. The fluoroquinolone resistance in UTI clinical
isolates was decreasing with increasing generations of
fluoroquinolone. Quinolone drug resistance in clinical
isolates was increasing with age and hospitalized
patients. Conclusion: Study showed an increased
fluoroquinolone resistance among uropathogenic
E. coli isolates of UTI. These increased antibiotic
resistance trends in UTI patients indicated that it is
imperative to rationalize the use of antimicrobials and
to use them conservatively. |
topic |
Urinary tract infections Escherichia coli Antibiotic sensitivity Fluoroquinolones |
url |
http://jkimsu.com/jkimsu-vol4no2/JKIMSU,Vol.4,No.2,April-June2015Page56-64.pdf |
work_keys_str_mv |
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