Physiologic Basis and Pathophysiologic Implications of the Diastolic Properties of the Cardiac Muscle
Although systole was for long considered the core of cardiac function, hemodynamic performance is evenly dependent on appropriate systolic and diastolic functions. The recognition that isolated diastolic dysfunction is the major culprit for approximately fifty percent of all heart failure cases impo...
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doaj-7890b6bf4ce34f3e9cb0ca16454679582020-11-25T02:36:27ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512010-01-01201010.1155/2010/807084807084Physiologic Basis and Pathophysiologic Implications of the Diastolic Properties of the Cardiac MuscleJoão Ferreira-Martins0Adelino F. Leite-Moreira1Department of Physiology, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, PortugalDepartment of Physiology, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, PortugalAlthough systole was for long considered the core of cardiac function, hemodynamic performance is evenly dependent on appropriate systolic and diastolic functions. The recognition that isolated diastolic dysfunction is the major culprit for approximately fifty percent of all heart failure cases imposes a deeper understanding of its underlying mechanisms so that better diagnostic and therapeutic strategies can be designed. Risk factors leading to diastolic dysfunction affect myocardial relaxation and/or its material properties by disrupting the homeostasis of cardiomyocytes as well as their relation with surrounding matrix and vascular structures. As a consequence, slower ventricular relaxation and higher myocardial stiffness may result in higher ventricular filling pressures and in the risk of hemodynamic decompensation. Thus, determining the mechanisms of diastolic function and their implications in the pathophysiology of heart failure with normal ejection fraction has become a prominent field in basic and clinical research.http://dx.doi.org/10.1155/2010/807084 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
João Ferreira-Martins Adelino F. Leite-Moreira |
spellingShingle |
João Ferreira-Martins Adelino F. Leite-Moreira Physiologic Basis and Pathophysiologic Implications of the Diastolic Properties of the Cardiac Muscle Journal of Biomedicine and Biotechnology |
author_facet |
João Ferreira-Martins Adelino F. Leite-Moreira |
author_sort |
João Ferreira-Martins |
title |
Physiologic Basis and Pathophysiologic Implications of the Diastolic Properties of the Cardiac Muscle |
title_short |
Physiologic Basis and Pathophysiologic Implications of the Diastolic Properties of the Cardiac Muscle |
title_full |
Physiologic Basis and Pathophysiologic Implications of the Diastolic Properties of the Cardiac Muscle |
title_fullStr |
Physiologic Basis and Pathophysiologic Implications of the Diastolic Properties of the Cardiac Muscle |
title_full_unstemmed |
Physiologic Basis and Pathophysiologic Implications of the Diastolic Properties of the Cardiac Muscle |
title_sort |
physiologic basis and pathophysiologic implications of the diastolic properties of the cardiac muscle |
publisher |
Hindawi Limited |
series |
Journal of Biomedicine and Biotechnology |
issn |
1110-7243 1110-7251 |
publishDate |
2010-01-01 |
description |
Although systole was for long considered the core of cardiac function, hemodynamic performance is evenly dependent on appropriate systolic and diastolic functions. The recognition that isolated diastolic dysfunction is the major culprit for approximately fifty percent of all heart failure cases imposes a deeper understanding of its underlying mechanisms so that better diagnostic and therapeutic strategies can be designed. Risk factors leading to diastolic dysfunction affect myocardial relaxation and/or its material properties by disrupting the homeostasis of cardiomyocytes as well as their relation with surrounding matrix and vascular structures. As a consequence, slower ventricular relaxation and higher myocardial stiffness may result in higher ventricular filling pressures and in the risk of hemodynamic decompensation. Thus, determining the mechanisms of diastolic function and their implications in the pathophysiology of heart failure with normal ejection fraction has become a prominent field in basic and clinical research. |
url |
http://dx.doi.org/10.1155/2010/807084 |
work_keys_str_mv |
AT joaoferreiramartins physiologicbasisandpathophysiologicimplicationsofthediastolicpropertiesofthecardiacmuscle AT adelinofleitemoreira physiologicbasisandpathophysiologicimplicationsofthediastolicpropertiesofthecardiacmuscle |
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1724800069109022720 |