B. abortus RNA is the component involved in the down-modulation of MHC-I expression on human monocytes via TLR8 and the EGFR pathway.
Despite eliciting a potent CD8+ T cell response, Brucella abortus is able to persist and establish a chronic infection inside its host. We have previously reported that the infection of human monocytes/macrophages with B. abortus inhibits the IFN-γ-induced MHC-I cell surface expression down-modulati...
Main Authors: | M Ayelén Milillo, Lis N Velásquez, Aldana Trotta, M Victoria Delpino, Fábio V Marinho, Luciana Balboa, Mónica Vermeulen, Sonia L Espindola, Nahuel Rodriguez-Rodrigues, Gabriela C Fernández, Sergio Costa Oliveira, Guillermo H Giambartolomei, Paula Barrionuevo |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-08-01
|
Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC5540288?pdf=render |
Similar Items
-
Platelets Promote Brucella abortus Monocyte Invasion by Establishing Complexes With Monocytes
by: Aldana Trotta, et al.
Published: (2018-05-01) -
Bacterial RNA Contributes to the Down-Modulation of MHC-II Expression on Monocytes/Macrophages Diminishing CD4+ T Cell Responses
by: M. Ayelén Milillo, et al.
Published: (2019-09-01) -
Brucella abortus Traverses Brain Microvascular Endothelial Cells Using Infected Monocytes as a Trojan Horse
by: María C. Miraglia, et al.
Published: (2018-06-01) -
Brucella abortus Infection Modulates 3T3-L1 Adipocyte Inflammatory Response and Inhibits Adipogenesis
by: Ayelén Ivana Pesce Viglietti, et al.
Published: (2020-09-01) -
B. Abortus Modulates Osteoblast Function Through the Induction of Autophagy
by: Ayelén Ivana Pesce Viglietti, et al.
Published: (2018-12-01)