Synthesis and physicochemical characterization of novel phenotypic probes targeting the nuclear factor-kappa B signaling pathway

Activation of nuclear factor-kappa B (NF-κB) and related upstream signal transduction pathways have long been associated with the pathogenesis of a variety of inflammatory diseases and has recently been implicated in the onset of cancer. This report provides a synthetic and compound-based property s...

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Bibliographic Details
Main Authors: Paul M. Hershberger, Satyamaheshwar Peddibhotla, E. Hampton Sessions, Daniela B. Divlianska, Ricardo G. Correa, Anthony B. Pinkerton, John C. Reed, Gregory P. Roth
Format: Article
Language:English
Published: Beilstein-Institut 2013-05-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Online Access:https://doi.org/10.3762/bjoc.9.103