Clinical efficacy of tirofiban combined with a Solitaire stent in treating acute ischemic stroke
This study explores the safety and effect of acute cerebral infarction treatment by microcatheter injection of tirofiban combined with a Solitaire AB stent and/or stent implantation. Emergency cerebral angiograms showing the responsible vascular occlusion of 120 acute cerebral infarction patients wh...
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doaj-78955c9acaa34e6ab0df7147967e84242020-11-25T02:48:40ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X521010.1590/1414-431x20198396S0100-879X2019001000603Clinical efficacy of tirofiban combined with a Solitaire stent in treating acute ischemic strokeYang ZhangQing-Qing ZhangCong FuLei WangGuan-Qun ZhangPei-Wei CaoGuo-Fang ChenXin-Min FuThis study explores the safety and effect of acute cerebral infarction treatment by microcatheter injection of tirofiban combined with a Solitaire AB stent and/or stent implantation. Emergency cerebral angiograms showing the responsible vascular occlusion of 120 acute cerebral infarction patients who underwent emergency endovascular thrombectomy were included in the study. These patients were randomly divided into two groups using the random number table method: treatment group (n=60) that received thrombectomy (with cerebral artery stents) combined with intracerebral injection of tirofiban and control group (n=60) that only received thrombectomy (with cerebral artery stents alone). The baseline data, cerebral angiography before and after surgery, hospitalization, and follow-up results of patients in these two groups were compared. Furthermore, the incidence of major adverse cerebrovascular events of these two groups was compared (90-day modified Rankin scale, a score of 0–2 indicates a good prognosis). The difference between baseline clinical data and brain angiography between these two groups was not statistically significant. Patients in the treatment group had a higher prevalence of thrombolysis in cerebral infarction grade 2b/3 than patients in the control group (88.3% (53/60) vs 66.7% (40/60), P=0.036). Moreover, the National Institutes of Health Stroke Scale scores 7 days after surgery and the 90-day prognosis were all better for the patients who received tirofiban (P=0.048 and P=0.024). Mechanical thrombectomy with Solitaire AB stents in combination with the injection of tirofiban through a microcatheter appears to be safe and effective for the endovascular treatment of acute ischemic stroke.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001000603&lng=en&tlng=enAcute ischemic strokeSolitaire AB stentEndovascular thrombectomyTirofiban |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yang Zhang Qing-Qing Zhang Cong Fu Lei Wang Guan-Qun Zhang Pei-Wei Cao Guo-Fang Chen Xin-Min Fu |
spellingShingle |
Yang Zhang Qing-Qing Zhang Cong Fu Lei Wang Guan-Qun Zhang Pei-Wei Cao Guo-Fang Chen Xin-Min Fu Clinical efficacy of tirofiban combined with a Solitaire stent in treating acute ischemic stroke Brazilian Journal of Medical and Biological Research Acute ischemic stroke Solitaire AB stent Endovascular thrombectomy Tirofiban |
author_facet |
Yang Zhang Qing-Qing Zhang Cong Fu Lei Wang Guan-Qun Zhang Pei-Wei Cao Guo-Fang Chen Xin-Min Fu |
author_sort |
Yang Zhang |
title |
Clinical efficacy of tirofiban combined with a Solitaire stent in treating acute ischemic stroke |
title_short |
Clinical efficacy of tirofiban combined with a Solitaire stent in treating acute ischemic stroke |
title_full |
Clinical efficacy of tirofiban combined with a Solitaire stent in treating acute ischemic stroke |
title_fullStr |
Clinical efficacy of tirofiban combined with a Solitaire stent in treating acute ischemic stroke |
title_full_unstemmed |
Clinical efficacy of tirofiban combined with a Solitaire stent in treating acute ischemic stroke |
title_sort |
clinical efficacy of tirofiban combined with a solitaire stent in treating acute ischemic stroke |
publisher |
Associação Brasileira de Divulgação Científica |
series |
Brazilian Journal of Medical and Biological Research |
issn |
1414-431X |
description |
This study explores the safety and effect of acute cerebral infarction treatment by microcatheter injection of tirofiban combined with a Solitaire AB stent and/or stent implantation. Emergency cerebral angiograms showing the responsible vascular occlusion of 120 acute cerebral infarction patients who underwent emergency endovascular thrombectomy were included in the study. These patients were randomly divided into two groups using the random number table method: treatment group (n=60) that received thrombectomy (with cerebral artery stents) combined with intracerebral injection of tirofiban and control group (n=60) that only received thrombectomy (with cerebral artery stents alone). The baseline data, cerebral angiography before and after surgery, hospitalization, and follow-up results of patients in these two groups were compared. Furthermore, the incidence of major adverse cerebrovascular events of these two groups was compared (90-day modified Rankin scale, a score of 0–2 indicates a good prognosis). The difference between baseline clinical data and brain angiography between these two groups was not statistically significant. Patients in the treatment group had a higher prevalence of thrombolysis in cerebral infarction grade 2b/3 than patients in the control group (88.3% (53/60) vs 66.7% (40/60), P=0.036). Moreover, the National Institutes of Health Stroke Scale scores 7 days after surgery and the 90-day prognosis were all better for the patients who received tirofiban (P=0.048 and P=0.024). Mechanical thrombectomy with Solitaire AB stents in combination with the injection of tirofiban through a microcatheter appears to be safe and effective for the endovascular treatment of acute ischemic stroke. |
topic |
Acute ischemic stroke Solitaire AB stent Endovascular thrombectomy Tirofiban |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001000603&lng=en&tlng=en |
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