Allelic variants of rs1800801 polymorphism in patients with stroke

• Main Authors: Svetlana Yu. Nikulina, Vladimir A. Shulman, Anna A. Chernova, Semen V. Prokopenko, Dmitrii A. Nikulin, Irirna M. Platunova, Svetlana S. Tretyakova, Aleksei A. Semenchukov, Olga V. Marilovtseva, Vladimir N. Chernov, Vladimir N. Maksimov, Anna A. Gurazheva
• Format: Article
• Language: English
• Published: Concilium Medicum 2019-12-01
• Series: КардиоСоматика
• Subjects: rs1800801; stroke; supraventricular tachycardia; arterial hypertension; dyslipidemia; atherosclerosis; hemostasis
• Online Access: https://cardiosomatics.orscience.ru/2221-7185/article/viewFile/45932/30934
• ISSN: 2221-7185; 2658-5707

Aim. To study the association of single nucleotide polymorphism (SNP) rs556621 (G>T) with the development of stroke in patients of the East Siberian population with cardiovascular pathology and risk factors. Material and methods. The study involved 260 patients with stroke (157 men and 103 women) and 272 patients of the control group (170 men and 102 women). The following cardiovascular pathology and risk factors were present in the patients of the main group: arterial hypertension, paroxysmal supraventricular tachycardias, dyslipidemia, atherosclerosis of the brachiocephalic arteries, disorders of the hemostatic system. All patients underwent clinical, instrumental and molecular genetic examination. Statistical processing of the material was carried out using the set of application programs Statistica for Windows 7.0, Excel and SPSS 22. Results. As a result of the study, no statistically significant associations of genotypes and alleles of the rs1800801 polymorphism (C>T) with stroke were found in any of the analyzed groups and subgroups. Conclusion. SNP rs1800801 (C>T) does not have a significant effect on the development of stroke in people of the East Siberian population, regardless of the preceding cardiovascular pathology and risk factors.