| Summary: | The mammalian genome is pervasively transcribed and the functional significance of many long non-coding RNA (lncRNA) transcripts are gradually being elucidated. <i>Metastasis Associated Lung Adenocarcinoma Transcript 1</i> (<i>MALAT1</i>) is one of the most well-studied lncRNAs. <i>MALAT1</i> is a highly conserved nuclear retained lncRNA that is abundantly expressed in cells and tissues and has been shown to play a role in regulating genes at both the transcriptional and post-transcriptional levels in a context-dependent manner. However, <i>Malat1</i> has been shown to be dispensable for normal development and viability in mice. Interestingly, accumulating evidence suggests that <i>MALAT1</i> plays an important role in numerous diseases including cancer. Here, we discuss the current state-of-knowledge in regard to <i>MALAT1</i> with respect to its function, role in diseases, and the potential therapeutic opportunities for targeting <i>MALAT1</i> using antisense oligonucleotides and small molecules.
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