Genetic Disorders of Bone or Osteodystrophies of Jaws—A Review
Bone is a specialized form of connective tissue, which is mineralized and made up of approximately 28% type I collagen and 5% noncollagenous matrix proteins. The properties of bone are very remarkable, because it is a dynamic tissue, undergoing constant renewal in response to mechanical, nutritional...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Georg Thieme Verlag KG
2021-03-01
|
Series: | Global Medical Genetics |
Subjects: | |
Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1724105 |
id |
doaj-78aa2de362fc4971a60606b21c060be6 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sirisha Vammi Jaya Lakshmi Bukyya Anulekha Avinash CK M. L. Avinash Tejasvi Archana Pokala Chanchala HP Priyanka Talwade Praveen Kumar Neela T. K. Shyamilee Mary Oshin Veenila Pantala |
spellingShingle |
Sirisha Vammi Jaya Lakshmi Bukyya Anulekha Avinash CK M. L. Avinash Tejasvi Archana Pokala Chanchala HP Priyanka Talwade Praveen Kumar Neela T. K. Shyamilee Mary Oshin Veenila Pantala Genetic Disorders of Bone or Osteodystrophies of Jaws—A Review Global Medical Genetics pth—parathyroid hormone cri—chronic renal failure rankl—receptor activator of nf-b ligand tgf—transforming growth factor m-csf—macrophage colony stimulating factor fgfr3—fibroblast growth factor receptor |
author_facet |
Sirisha Vammi Jaya Lakshmi Bukyya Anulekha Avinash CK M. L. Avinash Tejasvi Archana Pokala Chanchala HP Priyanka Talwade Praveen Kumar Neela T. K. Shyamilee Mary Oshin Veenila Pantala |
author_sort |
Sirisha Vammi |
title |
Genetic Disorders of Bone or Osteodystrophies of Jaws—A Review |
title_short |
Genetic Disorders of Bone or Osteodystrophies of Jaws—A Review |
title_full |
Genetic Disorders of Bone or Osteodystrophies of Jaws—A Review |
title_fullStr |
Genetic Disorders of Bone or Osteodystrophies of Jaws—A Review |
title_full_unstemmed |
Genetic Disorders of Bone or Osteodystrophies of Jaws—A Review |
title_sort |
genetic disorders of bone or osteodystrophies of jaws—a review |
publisher |
Georg Thieme Verlag KG |
series |
Global Medical Genetics |
issn |
2699-9404 |
publishDate |
2021-03-01 |
description |
Bone is a specialized form of connective tissue, which is mineralized and made up of approximately 28% type I collagen and 5% noncollagenous matrix proteins. The properties of bone are very remarkable, because it is a dynamic tissue, undergoing constant renewal in response to mechanical, nutritional, and hormonal influences. In 1978, “The International Nomenclature of Constitutional Diseases of Bone” divided bone disorders into two broad groups: osteochondrodysplasias and dysostoses. The osteochondrodysplasia group is further subdivided into two categories: dysplasias (abnormalities of bone and/or cartilage growth) and osteodystrophies (abnormalities of bone and/or cartilage texture). The dysplasias form the largest group of bone disorders, hence the loose term “skeletal dysplasia” that is often incorrectly used when referring to a condition that is in reality an osteodystrophy or dysostosis. The word “dystrophy” implies any condition of abnormal development. “Osteodystrophies,” as their name implies, are disturbances in the growth of bone. It is also known as osteodystrophia. It includes bone diseases that are neither inflammatory nor neoplastic but may be genetic, metabolic, or of unknown origin. Recent studies have shown that bone influences the activity of other organs, and the bone is also influenced by other organs and systems of the body, providing new insights and evidencing the complexity and dynamic nature of bone tissue. The 1,25-dihydroxyvitamin D3, or simply vitamin D, in association with other hormones and minerals, is responsible for mediating the intestinal absorption of calcium, which influences plasma calcium levels and bone metabolism. Diagnosis of the specific osteodystrophy type is a rather complex process and various biochemical markers and radiographic findings are used, so as to facilitate this condition. For diagnosis, we must consider the possibility of lesions related to bone metabolism altered by chronic renal failure (CRI), such as the different types of osteodystrophies, and differentiate from other possible neoplastic and/or inflammatory pathologies. It is important that the dentist must be aware of patients medical history, suffering from any systemic diseases, and identify the interference of the drugs and treatments to control them, so that we can able to perform the correct diagnosis and propose the most adequate treatment and outcomes of the individuals with bone lesions. |
topic |
pth—parathyroid hormone cri—chronic renal failure rankl—receptor activator of nf-b ligand tgf—transforming growth factor m-csf—macrophage colony stimulating factor fgfr3—fibroblast growth factor receptor |
url |
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1724105 |
work_keys_str_mv |
AT sirishavammi geneticdisordersofboneorosteodystrophiesofjawsareview AT jayalakshmibukyya geneticdisordersofboneorosteodystrophiesofjawsareview AT anulekhaavinashck geneticdisordersofboneorosteodystrophiesofjawsareview AT mlavinashtejasvi geneticdisordersofboneorosteodystrophiesofjawsareview AT archanapokala geneticdisordersofboneorosteodystrophiesofjawsareview AT chanchalahp geneticdisordersofboneorosteodystrophiesofjawsareview AT priyankatalwade geneticdisordersofboneorosteodystrophiesofjawsareview AT praveenkumarneela geneticdisordersofboneorosteodystrophiesofjawsareview AT tkshyamilee geneticdisordersofboneorosteodystrophiesofjawsareview AT maryoshin geneticdisordersofboneorosteodystrophiesofjawsareview AT veenilapantala geneticdisordersofboneorosteodystrophiesofjawsareview |
_version_ |
1721438532387471360 |
spelling |
doaj-78aa2de362fc4971a60606b21c060be62021-05-17T08:02:32ZengGeorg Thieme Verlag KGGlobal Medical Genetics2699-94042021-03-01080204105010.1055/s-0041-1724105Genetic Disorders of Bone or Osteodystrophies of Jaws—A ReviewSirisha Vammi0Jaya Lakshmi Bukyya1Anulekha Avinash CK2M. L. Avinash Tejasvi3Archana Pokala4Chanchala HP5Priyanka Talwade6Praveen Kumar Neela7T. K. Shyamilee8Mary Oshin9Veenila Pantala10Private Practitioner, Oral Medicine and Radiology, Vishakapatnam, Andhra Pradesh, IndiaDepartment of Oral Medicine and Radiology, Tirumala Institute of Dental Sciences, Nizamabad, Telangana, IndiaDepartment of Prosthodontics, Kamineni Institute of Dental Sciences, Narketpally, Telangana, IndiaDepartment of Oral Medicine and Radiology, Kamineni Institute of Dental Sciences, Narketpally, Telangana, IndiaDepartment of Oral Medicine and Radiology, Kamineni Institute of Dental Sciences, Narketpally, Telangana, IndiaDepartment of Pedodontics and Preventive Dentistry, JSS Dental College, Mysore, Karnataka, IndiaDepartment of Pedodontics and Preventive Dentistry, JSS Dental College, Mysore, Karnataka, IndiaDepartment of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, Telangana, IndiaPrivate Practitioner, MDS in Oral Pathology, Hyderabad, Telangana, IndiaDepartment of Oral Pathology, Tirumala Institute of Dental Sciences, Nizamabad, Telangana, IndiaDepartment of Oral Pathology, Tirumala Institute of Dental Sciences, Nizamabad, Telangana, IndiaBone is a specialized form of connective tissue, which is mineralized and made up of approximately 28% type I collagen and 5% noncollagenous matrix proteins. The properties of bone are very remarkable, because it is a dynamic tissue, undergoing constant renewal in response to mechanical, nutritional, and hormonal influences. In 1978, “The International Nomenclature of Constitutional Diseases of Bone” divided bone disorders into two broad groups: osteochondrodysplasias and dysostoses. The osteochondrodysplasia group is further subdivided into two categories: dysplasias (abnormalities of bone and/or cartilage growth) and osteodystrophies (abnormalities of bone and/or cartilage texture). The dysplasias form the largest group of bone disorders, hence the loose term “skeletal dysplasia” that is often incorrectly used when referring to a condition that is in reality an osteodystrophy or dysostosis. The word “dystrophy” implies any condition of abnormal development. “Osteodystrophies,” as their name implies, are disturbances in the growth of bone. It is also known as osteodystrophia. It includes bone diseases that are neither inflammatory nor neoplastic but may be genetic, metabolic, or of unknown origin. Recent studies have shown that bone influences the activity of other organs, and the bone is also influenced by other organs and systems of the body, providing new insights and evidencing the complexity and dynamic nature of bone tissue. The 1,25-dihydroxyvitamin D3, or simply vitamin D, in association with other hormones and minerals, is responsible for mediating the intestinal absorption of calcium, which influences plasma calcium levels and bone metabolism. Diagnosis of the specific osteodystrophy type is a rather complex process and various biochemical markers and radiographic findings are used, so as to facilitate this condition. For diagnosis, we must consider the possibility of lesions related to bone metabolism altered by chronic renal failure (CRI), such as the different types of osteodystrophies, and differentiate from other possible neoplastic and/or inflammatory pathologies. It is important that the dentist must be aware of patients medical history, suffering from any systemic diseases, and identify the interference of the drugs and treatments to control them, so that we can able to perform the correct diagnosis and propose the most adequate treatment and outcomes of the individuals with bone lesions.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1724105pth—parathyroid hormonecri—chronic renal failurerankl—receptor activator of nf-b ligandtgf—transforming growth factorm-csf—macrophage colony stimulating factorfgfr3—fibroblast growth factor receptor |