The Pharmacological Activity of <i>Camellia sinensis</i> (L.) Kuntze on Metabolic and Endocrine Disorders: A Systematic Review
Tea made from <i>Camellia sinensis</i> leaves is one of the most consumed beverages worldwide. This systematic review aims to update <i>Camellia sinensis</i> pharmacological activity on metabolic and endocrine disorders. Inclusion criteria were preclinical and clinical studie...
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doaj-78b4117b73ac4495ad6d05a49ce9b0e12020-11-25T02:23:40ZengMDPI AGBiomolecules2218-273X2020-04-011060360310.3390/biom10040603The Pharmacological Activity of <i>Camellia sinensis</i> (L.) Kuntze on Metabolic and Endocrine Disorders: A Systematic ReviewMarta Sánchez0Elena González-Burgos1Irene Iglesias2Rafael Lozano3M. Pilar Gómez-Serranillos4Department of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, Universidad Complutense de Madrid, Plaza Ramon y Cajal s/n, Ciudad Universitaria, 28040 Madrid, SpainDepartment of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, Universidad Complutense de Madrid, Plaza Ramon y Cajal s/n, Ciudad Universitaria, 28040 Madrid, SpainDepartment of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, Universidad Complutense de Madrid, Plaza Ramon y Cajal s/n, Ciudad Universitaria, 28040 Madrid, SpainDepartment of Chemistry in Pharmaceutical Sciences, Faculty of Pharmacy, Universidad Complutense de Madrid, Plaza Ramon y Cajal s/n, Ciudad Universitaria, 28040 Madrid, SpainDepartment of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, Universidad Complutense de Madrid, Plaza Ramon y Cajal s/n, Ciudad Universitaria, 28040 Madrid, SpainTea made from <i>Camellia sinensis</i> leaves is one of the most consumed beverages worldwide. This systematic review aims to update <i>Camellia sinensis</i> pharmacological activity on metabolic and endocrine disorders. Inclusion criteria were preclinical and clinical studies of tea extracts and isolated compounds on osteoporosis, hypertension, diabetes, metabolic syndrome, hypercholesterolemia, and obesity written in English between 2014 and 2019 and published in Pubmed, Science Direct, and Scopus. From a total of 1384 studies, 80 reports met inclusion criteria. Most papers were published in 2015 (29.3%) and 2017 (20.6%), conducted in China (28.75%), US (12.5%), and South Korea (10%) and carried out with extracts (67.5%, especially green tea) and isolated compounds (41.25%, especially epigallocatechin gallate). Most pharmacological studies were <i>in vitro </i>and <i>in vivo</i> studies focused on diabetes and obesity. Clinical trials, although they have demonstrated promising results, are very limited. Future research should be aimed at providing more clinical evidence on less studied pathologies such as osteoporosis, hypertension, and metabolic syndrome. Given the close relationship among all endocrine disorders, it would be of interest to find a standard dose of tea or their bioactive constituents that would be beneficial for all of them.https://www.mdpi.com/2218-273X/10/4/603<i>Camellia sinensis</i>metabolic disordersendocrine disorderstea |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marta Sánchez Elena González-Burgos Irene Iglesias Rafael Lozano M. Pilar Gómez-Serranillos |
spellingShingle |
Marta Sánchez Elena González-Burgos Irene Iglesias Rafael Lozano M. Pilar Gómez-Serranillos The Pharmacological Activity of <i>Camellia sinensis</i> (L.) Kuntze on Metabolic and Endocrine Disorders: A Systematic Review Biomolecules <i>Camellia sinensis</i> metabolic disorders endocrine disorders tea |
author_facet |
Marta Sánchez Elena González-Burgos Irene Iglesias Rafael Lozano M. Pilar Gómez-Serranillos |
author_sort |
Marta Sánchez |
title |
The Pharmacological Activity of <i>Camellia sinensis</i> (L.) Kuntze on Metabolic and Endocrine Disorders: A Systematic Review |
title_short |
The Pharmacological Activity of <i>Camellia sinensis</i> (L.) Kuntze on Metabolic and Endocrine Disorders: A Systematic Review |
title_full |
The Pharmacological Activity of <i>Camellia sinensis</i> (L.) Kuntze on Metabolic and Endocrine Disorders: A Systematic Review |
title_fullStr |
The Pharmacological Activity of <i>Camellia sinensis</i> (L.) Kuntze on Metabolic and Endocrine Disorders: A Systematic Review |
title_full_unstemmed |
The Pharmacological Activity of <i>Camellia sinensis</i> (L.) Kuntze on Metabolic and Endocrine Disorders: A Systematic Review |
title_sort |
pharmacological activity of <i>camellia sinensis</i> (l.) kuntze on metabolic and endocrine disorders: a systematic review |
publisher |
MDPI AG |
series |
Biomolecules |
issn |
2218-273X |
publishDate |
2020-04-01 |
description |
Tea made from <i>Camellia sinensis</i> leaves is one of the most consumed beverages worldwide. This systematic review aims to update <i>Camellia sinensis</i> pharmacological activity on metabolic and endocrine disorders. Inclusion criteria were preclinical and clinical studies of tea extracts and isolated compounds on osteoporosis, hypertension, diabetes, metabolic syndrome, hypercholesterolemia, and obesity written in English between 2014 and 2019 and published in Pubmed, Science Direct, and Scopus. From a total of 1384 studies, 80 reports met inclusion criteria. Most papers were published in 2015 (29.3%) and 2017 (20.6%), conducted in China (28.75%), US (12.5%), and South Korea (10%) and carried out with extracts (67.5%, especially green tea) and isolated compounds (41.25%, especially epigallocatechin gallate). Most pharmacological studies were <i>in vitro </i>and <i>in vivo</i> studies focused on diabetes and obesity. Clinical trials, although they have demonstrated promising results, are very limited. Future research should be aimed at providing more clinical evidence on less studied pathologies such as osteoporosis, hypertension, and metabolic syndrome. Given the close relationship among all endocrine disorders, it would be of interest to find a standard dose of tea or their bioactive constituents that would be beneficial for all of them. |
topic |
<i>Camellia sinensis</i> metabolic disorders endocrine disorders tea |
url |
https://www.mdpi.com/2218-273X/10/4/603 |
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