Protective Effect of Qiliqiangxin Capsule on Energy Metabolism and Myocardial Mitochondria in Pressure Overload Heart Failure Rats
Qiliqiangxin capsule (QL) was developed under the guidance of TCM theory of collateral disease and had been shown to be effective and safe for the treatment of heart failure. The present study explored the role of and mechanism by which the herbal compounds QL act on energy metabolism, in vivo, in p...
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doaj-78b8b894af084bcf88e8362b85b020b72020-11-25T00:22:29ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882013-01-01201310.1155/2013/378298378298Protective Effect of Qiliqiangxin Capsule on Energy Metabolism and Myocardial Mitochondria in Pressure Overload Heart Failure RatsJunfang Zhang0Cong Wei1Hongtao Wang2Siwen Tang3Zhenhua Jia4Lei Wang5Dengfeng Xu6Yiling Wu7Integrative Medicine Department, Hebei Medical University, 361 Zhongshan Road, Shijiazhuang 050017, ChinaHebei Yiling Medical Research Institute, Shijiazhuang 050035, ChinaHebei Yiling Medical Research Institute, Shijiazhuang 050035, ChinaKey Research Centre of State Administration of Traditional Chinese Medicine (Collateral Disease of Cardiovascular), Shijiazhuang 050035, ChinaKey Research Centre of State Administration of Traditional Chinese Medicine (Collateral Disease of Cardiovascular), Shijiazhuang 050035, ChinaIntegrative Medicine Department, Hebei Medical University, 361 Zhongshan Road, Shijiazhuang 050017, ChinaKey Research Centre of State Administration of Traditional Chinese Medicine (Collateral Disease of Cardiovascular), Shijiazhuang 050035, ChinaIntegrative Medicine Department, Hebei Medical University, 361 Zhongshan Road, Shijiazhuang 050017, ChinaQiliqiangxin capsule (QL) was developed under the guidance of TCM theory of collateral disease and had been shown to be effective and safe for the treatment of heart failure. The present study explored the role of and mechanism by which the herbal compounds QL act on energy metabolism, in vivo, in pressure overload heart failure. SD rats received ascending aorta constriction (TAC) to establish a model of myocardial hypertrophy. The animals were treated orally for a period of six weeks. QL significantly inhibited cardiac hypertrophy due to ascending aortic constriction and improved hemodynamics. This effect was linked to the expression levels of the signaling factors in connection with upregulated energy and the regulation of glucose and lipid substrate metabolism and with a decrease in metabolic intermediate products and the protection of mitochondrial function. It is concluded that QL may regulate the glycolipid substrate metabolism by activating AMPK/PGC-1α axis and reduce the accumulation of free fatty acids and lactic acid, to protect cardiac myocytes and mitochondrial function.http://dx.doi.org/10.1155/2013/378298 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Junfang Zhang Cong Wei Hongtao Wang Siwen Tang Zhenhua Jia Lei Wang Dengfeng Xu Yiling Wu |
spellingShingle |
Junfang Zhang Cong Wei Hongtao Wang Siwen Tang Zhenhua Jia Lei Wang Dengfeng Xu Yiling Wu Protective Effect of Qiliqiangxin Capsule on Energy Metabolism and Myocardial Mitochondria in Pressure Overload Heart Failure Rats Evidence-Based Complementary and Alternative Medicine |
author_facet |
Junfang Zhang Cong Wei Hongtao Wang Siwen Tang Zhenhua Jia Lei Wang Dengfeng Xu Yiling Wu |
author_sort |
Junfang Zhang |
title |
Protective Effect of Qiliqiangxin Capsule on Energy Metabolism and Myocardial Mitochondria in Pressure Overload Heart Failure Rats |
title_short |
Protective Effect of Qiliqiangxin Capsule on Energy Metabolism and Myocardial Mitochondria in Pressure Overload Heart Failure Rats |
title_full |
Protective Effect of Qiliqiangxin Capsule on Energy Metabolism and Myocardial Mitochondria in Pressure Overload Heart Failure Rats |
title_fullStr |
Protective Effect of Qiliqiangxin Capsule on Energy Metabolism and Myocardial Mitochondria in Pressure Overload Heart Failure Rats |
title_full_unstemmed |
Protective Effect of Qiliqiangxin Capsule on Energy Metabolism and Myocardial Mitochondria in Pressure Overload Heart Failure Rats |
title_sort |
protective effect of qiliqiangxin capsule on energy metabolism and myocardial mitochondria in pressure overload heart failure rats |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2013-01-01 |
description |
Qiliqiangxin capsule (QL) was developed under the guidance of TCM theory of collateral disease and had been shown to be effective and safe for the treatment of heart failure. The present study explored the role of and mechanism by which the herbal compounds QL act on energy metabolism, in vivo, in pressure overload heart failure. SD rats received ascending aorta constriction (TAC) to establish a model of myocardial hypertrophy. The animals were treated orally for a period of six weeks. QL significantly inhibited cardiac hypertrophy due to ascending aortic constriction and improved hemodynamics. This effect was linked to the expression levels of the signaling factors in connection with upregulated energy and the regulation of glucose and lipid substrate metabolism and with a decrease in metabolic intermediate products and the protection of mitochondrial function. It is concluded that QL may regulate the glycolipid substrate metabolism by activating AMPK/PGC-1α axis and reduce the accumulation of free fatty acids and lactic acid, to protect cardiac myocytes and mitochondrial function. |
url |
http://dx.doi.org/10.1155/2013/378298 |
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