Mitochondria, Endothelial Cell Function and Vascular Diseases
Mitochondria are perhaps the most sophisticated and dynamic responsive sensing systems in eukaryotic cells. The role of mitochondria goes beyond their capacity to create molecular fuel and includes the generation of reactive oxygen species, the regulation of calcium, and the activation of cell death...
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doaj-78baeed1300f4ac18168c2fa133b127b2020-11-24T22:40:26ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2014-05-01510.3389/fphys.2014.0017578367Mitochondria, Endothelial Cell Function and Vascular DiseasesXiaoqiang eTang0Yu-Xuan eLuo1Hou-Zao eChen2De-Pei eLiu3Chinese Academy of Medical Sciences &Peking Union Medical CollegeChinese Academy of Medical Sciences &Peking Union Medical CollegeChinese Academy of Medical Sciences &Peking Union Medical CollegeChinese Academy of Medical Sciences &Peking Union Medical CollegeMitochondria are perhaps the most sophisticated and dynamic responsive sensing systems in eukaryotic cells. The role of mitochondria goes beyond their capacity to create molecular fuel and includes the generation of reactive oxygen species, the regulation of calcium, and the activation of cell death. In endothelial cells, mitochondria have a profound impact on cellular function under both healthy and diseased conditions. In this review, we summarize the basic functions of mitochondria in endothelial cells and discuss the roles of mitochondria in endothelial dysfunction and vascular diseases, including atherosclerosis, diabetic vascular dysfunction, pulmonary artery hypertension and hypertension. Finally, the potential therapeutic strategies to improve mitochondrial function in endothelial cells and vascular diseases are also discussed, with a focus on mitochondrial-targeted antioxidants and calorie restriction.http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00175/fullAntioxidantsCaloric RestrictionDiabetes MellitusEndothelial CellsHypertensionMitochondria |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiaoqiang eTang Yu-Xuan eLuo Hou-Zao eChen De-Pei eLiu |
spellingShingle |
Xiaoqiang eTang Yu-Xuan eLuo Hou-Zao eChen De-Pei eLiu Mitochondria, Endothelial Cell Function and Vascular Diseases Frontiers in Physiology Antioxidants Caloric Restriction Diabetes Mellitus Endothelial Cells Hypertension Mitochondria |
author_facet |
Xiaoqiang eTang Yu-Xuan eLuo Hou-Zao eChen De-Pei eLiu |
author_sort |
Xiaoqiang eTang |
title |
Mitochondria, Endothelial Cell Function and Vascular Diseases |
title_short |
Mitochondria, Endothelial Cell Function and Vascular Diseases |
title_full |
Mitochondria, Endothelial Cell Function and Vascular Diseases |
title_fullStr |
Mitochondria, Endothelial Cell Function and Vascular Diseases |
title_full_unstemmed |
Mitochondria, Endothelial Cell Function and Vascular Diseases |
title_sort |
mitochondria, endothelial cell function and vascular diseases |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2014-05-01 |
description |
Mitochondria are perhaps the most sophisticated and dynamic responsive sensing systems in eukaryotic cells. The role of mitochondria goes beyond their capacity to create molecular fuel and includes the generation of reactive oxygen species, the regulation of calcium, and the activation of cell death. In endothelial cells, mitochondria have a profound impact on cellular function under both healthy and diseased conditions. In this review, we summarize the basic functions of mitochondria in endothelial cells and discuss the roles of mitochondria in endothelial dysfunction and vascular diseases, including atherosclerosis, diabetic vascular dysfunction, pulmonary artery hypertension and hypertension. Finally, the potential therapeutic strategies to improve mitochondrial function in endothelial cells and vascular diseases are also discussed, with a focus on mitochondrial-targeted antioxidants and calorie restriction. |
topic |
Antioxidants Caloric Restriction Diabetes Mellitus Endothelial Cells Hypertension Mitochondria |
url |
http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00175/full |
work_keys_str_mv |
AT xiaoqiangetang mitochondriaendothelialcellfunctionandvasculardiseases AT yuxuaneluo mitochondriaendothelialcellfunctionandvasculardiseases AT houzaoechen mitochondriaendothelialcellfunctionandvasculardiseases AT depeieliu mitochondriaendothelialcellfunctionandvasculardiseases |
_version_ |
1725704982624206848 |