The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal Patterns
Inner ear formation requires that a series of cell fate decisions and morphogenetic events occur in a precise temporal and spatial pattern. Previous studies have shown that transcription factors, including Pax2, Sox2, and Prox1, play important roles during the inner ear development. However, the tem...
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2018-01-01
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Series: | Neural Plasticity |
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doaj-78c0a6d481a640b8a36afbf0ceef10b22020-11-24T21:47:43ZengHindawi LimitedNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/75132587513258The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal PatternsShaofeng Liu0Yunfeng Wang1Yongtian Lu2Wen Li3Wenjing Liu4Jun Ma5Fuqin Sun6Mao Li7Zheng-Yi Chen8Kaiming Su9Wenyan Li10Department of Otolaryngology-Head and Neck Surgery, Yijisan Hospital of Wanan Medical College, Wuhu, Anhui 241001, ChinaENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, ChinaOtorhinolaryngology Department of the Shenzhen Second People’s Hospital (First Affiliated Hospital of Shenzhen University), Shenzhen, ChinaENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Yijisan Hospital of Wanan Medical College, Wuhu, Anhui 241001, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Yijisan Hospital of Wanan Medical College, Wuhu, Anhui 241001, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Yijisan Hospital of Wanan Medical College, Wuhu, Anhui 241001, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Yijisan Hospital of Wanan Medical College, Wuhu, Anhui 241001, ChinaDepartment of Otolaryngology and Program in Neuroscience, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USADepartment of Otolaryngology, Head and Neck Surgery, Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200230, ChinaENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, ChinaInner ear formation requires that a series of cell fate decisions and morphogenetic events occur in a precise temporal and spatial pattern. Previous studies have shown that transcription factors, including Pax2, Sox2, and Prox1, play important roles during the inner ear development. However, the temporospatial expression patterns among these transcription factors are poorly understood. In the current study, we present a comprehensive description of the temporal and spatial expression profiles of Pax2, Sox2, and Prox1 during auditory and vestibular sensory organ development in mice. Using immunohistochemical analyses, we show that Sox2 and Pax2 are both expressed in the prosensory cells (the developing hair cells), but Sox2 is later restricted to only the supporting cells of the organ of Corti. In the vestibular sensory organ, however, the Pax2 expression is localized in hair cells at postnatal day 7, while Sox2 is still expressed in both the hair cells and supporting cells at that time. Prox1 was transiently expressed in the presumptive hair cells and developing supporting cells, and lower Prox1 expression was observed in the vestibular sensory organ compared to the organ of Corti. The different expression patterns of these transcription factors in the developing auditory and vestibular sensory organs suggest that they play different roles in the development of the sensory epithelia and might help to shape the respective sensory structures.http://dx.doi.org/10.1155/2018/7513258 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shaofeng Liu Yunfeng Wang Yongtian Lu Wen Li Wenjing Liu Jun Ma Fuqin Sun Mao Li Zheng-Yi Chen Kaiming Su Wenyan Li |
spellingShingle |
Shaofeng Liu Yunfeng Wang Yongtian Lu Wen Li Wenjing Liu Jun Ma Fuqin Sun Mao Li Zheng-Yi Chen Kaiming Su Wenyan Li The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal Patterns Neural Plasticity |
author_facet |
Shaofeng Liu Yunfeng Wang Yongtian Lu Wen Li Wenjing Liu Jun Ma Fuqin Sun Mao Li Zheng-Yi Chen Kaiming Su Wenyan Li |
author_sort |
Shaofeng Liu |
title |
The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal Patterns |
title_short |
The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal Patterns |
title_full |
The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal Patterns |
title_fullStr |
The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal Patterns |
title_full_unstemmed |
The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal Patterns |
title_sort |
key transcription factor expression in the developing vestibular and auditory sensory organs: a comprehensive comparison of spatial and temporal patterns |
publisher |
Hindawi Limited |
series |
Neural Plasticity |
issn |
2090-5904 1687-5443 |
publishDate |
2018-01-01 |
description |
Inner ear formation requires that a series of cell fate decisions and morphogenetic events occur in a precise temporal and spatial pattern. Previous studies have shown that transcription factors, including Pax2, Sox2, and Prox1, play important roles during the inner ear development. However, the temporospatial expression patterns among these transcription factors are poorly understood. In the current study, we present a comprehensive description of the temporal and spatial expression profiles of Pax2, Sox2, and Prox1 during auditory and vestibular sensory organ development in mice. Using immunohistochemical analyses, we show that Sox2 and Pax2 are both expressed in the prosensory cells (the developing hair cells), but Sox2 is later restricted to only the supporting cells of the organ of Corti. In the vestibular sensory organ, however, the Pax2 expression is localized in hair cells at postnatal day 7, while Sox2 is still expressed in both the hair cells and supporting cells at that time. Prox1 was transiently expressed in the presumptive hair cells and developing supporting cells, and lower Prox1 expression was observed in the vestibular sensory organ compared to the organ of Corti. The different expression patterns of these transcription factors in the developing auditory and vestibular sensory organs suggest that they play different roles in the development of the sensory epithelia and might help to shape the respective sensory structures. |
url |
http://dx.doi.org/10.1155/2018/7513258 |
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