Simultaneous quantification of mRNA and protein in single cells reveals post-transcriptional effects of genetic variation

Simultaneous quantification of mRNA and protein in single cells reveals post-transcriptional effects of genetic variation

Trans-acting DNA variants may specifically affect mRNA or protein levels of genes located throughout the genome. However, prior work compared trans-acting loci mapped in separate studies, many of which had limited statistical power. Here, we developed a CRISPR-based system for simultaneous quantific...

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Bibliographic Details
Main Authors: Christian Brion, Sheila M Lutz, Frank Wolfgang Albert
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
eQTL
pQTL
CRISPR
complex traits
gene expression regulation
YAK1
Online Access:https://elifesciences.org/articles/60645

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