The value of sex-specific abdominal visceral fat as measured via CT as a predictor of clear renal cell carcinoma T stage
Although much is known about how adipose tissue affects the development of clear cell renal carcinoma (ccRCC), little information is available for the utility of sex-specific abdominal visceral fat composition as a predictor of clear cell renal carcinoma (ccRCC) T stage. We conducted CT-based sex-sp...
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doaj-78d039aa037a4370835882949a665f8c2021-06-02T08:43:39ZengTaylor & Francis GroupAdipocyte2162-39452162-397X2021-01-0110128529210.1080/21623945.2021.19249571924957The value of sex-specific abdominal visceral fat as measured via CT as a predictor of clear renal cell carcinoma T stageHao Guo0Wenlei Zhao1Aijie Wang2Mingzhuo Li3Heng Ma4Fang Wang5Qing Wang6Xinru Ba7Qilu Hospital, Cheeloo College of Medicine, Shandong UniversityYuhuangding Hospital, Qingdao University School of MedicineYaitai Shan HospitalThe First Affilicated Hospital of Shandong First Medical UniversityYuhuangding Hospital, Qingdao University School of MedicineQilu Hospital, Cheeloo College of Medicine, Shandong UniversityQilu Hospital, Cheeloo College of Medicine, Shandong UniversityYaitai Shan HospitalAlthough much is known about how adipose tissue affects the development of clear cell renal carcinoma (ccRCC), little information is available for the utility of sex-specific abdominal visceral fat composition as a predictor of clear cell renal carcinoma (ccRCC) T stage. We conducted CT-based sex-specific abdominal fat measurements in ccRCC patients to assess whether VFA distribution could predict the ccRCC T stage. In total, 253 patients (182 males and 71 females) from our hospital with pathologically confirmed ccRCC (178 low T-stage and 75 high T-stage) were retrospectively reviewed for the present study. Computed tomography (CT) scans were assessed using ImageJ to differentiate between the visceral and subcutaneous fat areas (VFA and SFA), after which the relative VFA (rVFA) and total fat area (TFA) were computed. The relationships between these fat area-related variables, patient age, sex, and BMI, and ccRCC T stage were then evaluated through univariate and multivariate logistic regression analysis to clarify the association between general or sex-specific abdominal visceral fat and T stage. Following adjustment for age, males with high T stage ccRCC exhibited an increased rVFA as compared to males with low T stage ccRCC, with the same relationship being observed among females. This association between rVFA and high T stage was confirmed through both univariate and multivariate models. As thus, sex-specific visceral fat composition is a reliable independent predictor that can identify both male and female patients with high T stage ccRCC.http://dx.doi.org/10.1080/21623945.2021.1924957clear renal cell carcinomaabdominalobesitycomputed tomographyt stage |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hao Guo Wenlei Zhao Aijie Wang Mingzhuo Li Heng Ma Fang Wang Qing Wang Xinru Ba |
spellingShingle |
Hao Guo Wenlei Zhao Aijie Wang Mingzhuo Li Heng Ma Fang Wang Qing Wang Xinru Ba The value of sex-specific abdominal visceral fat as measured via CT as a predictor of clear renal cell carcinoma T stage Adipocyte clear renal cell carcinoma abdominal obesity computed tomography t stage |
author_facet |
Hao Guo Wenlei Zhao Aijie Wang Mingzhuo Li Heng Ma Fang Wang Qing Wang Xinru Ba |
author_sort |
Hao Guo |
title |
The value of sex-specific abdominal visceral fat as measured via CT as a predictor of clear renal cell carcinoma T stage |
title_short |
The value of sex-specific abdominal visceral fat as measured via CT as a predictor of clear renal cell carcinoma T stage |
title_full |
The value of sex-specific abdominal visceral fat as measured via CT as a predictor of clear renal cell carcinoma T stage |
title_fullStr |
The value of sex-specific abdominal visceral fat as measured via CT as a predictor of clear renal cell carcinoma T stage |
title_full_unstemmed |
The value of sex-specific abdominal visceral fat as measured via CT as a predictor of clear renal cell carcinoma T stage |
title_sort |
value of sex-specific abdominal visceral fat as measured via ct as a predictor of clear renal cell carcinoma t stage |
publisher |
Taylor & Francis Group |
series |
Adipocyte |
issn |
2162-3945 2162-397X |
publishDate |
2021-01-01 |
description |
Although much is known about how adipose tissue affects the development of clear cell renal carcinoma (ccRCC), little information is available for the utility of sex-specific abdominal visceral fat composition as a predictor of clear cell renal carcinoma (ccRCC) T stage. We conducted CT-based sex-specific abdominal fat measurements in ccRCC patients to assess whether VFA distribution could predict the ccRCC T stage. In total, 253 patients (182 males and 71 females) from our hospital with pathologically confirmed ccRCC (178 low T-stage and 75 high T-stage) were retrospectively reviewed for the present study. Computed tomography (CT) scans were assessed using ImageJ to differentiate between the visceral and subcutaneous fat areas (VFA and SFA), after which the relative VFA (rVFA) and total fat area (TFA) were computed. The relationships between these fat area-related variables, patient age, sex, and BMI, and ccRCC T stage were then evaluated through univariate and multivariate logistic regression analysis to clarify the association between general or sex-specific abdominal visceral fat and T stage. Following adjustment for age, males with high T stage ccRCC exhibited an increased rVFA as compared to males with low T stage ccRCC, with the same relationship being observed among females. This association between rVFA and high T stage was confirmed through both univariate and multivariate models. As thus, sex-specific visceral fat composition is a reliable independent predictor that can identify both male and female patients with high T stage ccRCC. |
topic |
clear renal cell carcinoma abdominal obesity computed tomography t stage |
url |
http://dx.doi.org/10.1080/21623945.2021.1924957 |
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