Radiation Recall Pneumonitis Induced by Anti-PD-1 Blockade: A Case Report and Review of the Literature
Background: Radiation recall pneumonitis (RRP) is an unpredictable but relatively severe subclinical radiation damage which occurs in the previously irradiated fields of pulmonary tissue after administration of a systemic agent. Previous reports of RRP were mainly attributed to chemotherapy and mole...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-04-01
|
Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.00561/full |
id |
doaj-78d1794cd38e491d94dcc399d40b9b3c |
---|---|
record_format |
Article |
spelling |
doaj-78d1794cd38e491d94dcc399d40b9b3c2020-11-25T03:27:51ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-04-011010.3389/fonc.2020.00561512617Radiation Recall Pneumonitis Induced by Anti-PD-1 Blockade: A Case Report and Review of the LiteratureYu Chen0Yu Chen1Zhaoqin Huang2Ligang Xing3Xiangjiao Meng4Jinming Yu5Jinming Yu6Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaCheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaBackground: Radiation recall pneumonitis (RRP) is an unpredictable but relatively severe subclinical radiation damage which occurs in the previously irradiated fields of pulmonary tissue after administration of a systemic agent. Previous reports of RRP were mainly attributed to chemotherapy and molecular-target agents. RRP induced by immunotherapy has been rarely reported. Here we describe a case of a novel pattern of RRP induced by anti-PD-1 blockade Camrelizumab 2 years after radiotherapy, with some focus on further understanding of this phenomenon.Case Report: A 64-year-old man with non-small cell lung cancer (NSCLC) received two cycles of chemotherapy with cisplatin and pemetrexed first. Subsequently, he underwent concomitant chemoradiotherapy with cisplatin and pemetrexed to simultaneous integrated boost (SIB) radiotherapy. After 15 months, due to tumor progression and brain metastasis, he started with administration of anti-PD-1 blockade Camrelizumab (200 mg q2w) and stereotactic radiosurgery (SRS). The patient developed fever, dyspnea and cough after the eighth administration of Camrelizumab. Meanwhile, his chest CT revealed patchy consolidation and ground-glass opacities localized within the previously irradiated area. Subsequent treatment regimen was adjusted to 80 mg q12h prednisolone with discontinuation of Camrelizumab. Then the symptoms gradually eased and reexamination of CT showed significant improvement in RRP after 2 weeks.Conclusion: Our case report presents a novel pattern of RRP induced by anti-PD-1 blockade Camrelizumab 2 years after radiotherapy. This indicates that previous radiotherapy combined with subsequent anti-PD-1 blockade has a potential to cause overlapping damage to lung, suggesting that intensive attention might be needed for patients who are treated with anti-PD-1 blockade in conjunction with a prior history of thoracic radiation.https://www.frontiersin.org/article/10.3389/fonc.2020.00561/fullradiation recall pneumonitis (RRP)anti-PD-1 blockadethoracic radiationimmunotherapyCamrelizumab |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu Chen Yu Chen Zhaoqin Huang Ligang Xing Xiangjiao Meng Jinming Yu Jinming Yu |
spellingShingle |
Yu Chen Yu Chen Zhaoqin Huang Ligang Xing Xiangjiao Meng Jinming Yu Jinming Yu Radiation Recall Pneumonitis Induced by Anti-PD-1 Blockade: A Case Report and Review of the Literature Frontiers in Oncology radiation recall pneumonitis (RRP) anti-PD-1 blockade thoracic radiation immunotherapy Camrelizumab |
author_facet |
Yu Chen Yu Chen Zhaoqin Huang Ligang Xing Xiangjiao Meng Jinming Yu Jinming Yu |
author_sort |
Yu Chen |
title |
Radiation Recall Pneumonitis Induced by Anti-PD-1 Blockade: A Case Report and Review of the Literature |
title_short |
Radiation Recall Pneumonitis Induced by Anti-PD-1 Blockade: A Case Report and Review of the Literature |
title_full |
Radiation Recall Pneumonitis Induced by Anti-PD-1 Blockade: A Case Report and Review of the Literature |
title_fullStr |
Radiation Recall Pneumonitis Induced by Anti-PD-1 Blockade: A Case Report and Review of the Literature |
title_full_unstemmed |
Radiation Recall Pneumonitis Induced by Anti-PD-1 Blockade: A Case Report and Review of the Literature |
title_sort |
radiation recall pneumonitis induced by anti-pd-1 blockade: a case report and review of the literature |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2020-04-01 |
description |
Background: Radiation recall pneumonitis (RRP) is an unpredictable but relatively severe subclinical radiation damage which occurs in the previously irradiated fields of pulmonary tissue after administration of a systemic agent. Previous reports of RRP were mainly attributed to chemotherapy and molecular-target agents. RRP induced by immunotherapy has been rarely reported. Here we describe a case of a novel pattern of RRP induced by anti-PD-1 blockade Camrelizumab 2 years after radiotherapy, with some focus on further understanding of this phenomenon.Case Report: A 64-year-old man with non-small cell lung cancer (NSCLC) received two cycles of chemotherapy with cisplatin and pemetrexed first. Subsequently, he underwent concomitant chemoradiotherapy with cisplatin and pemetrexed to simultaneous integrated boost (SIB) radiotherapy. After 15 months, due to tumor progression and brain metastasis, he started with administration of anti-PD-1 blockade Camrelizumab (200 mg q2w) and stereotactic radiosurgery (SRS). The patient developed fever, dyspnea and cough after the eighth administration of Camrelizumab. Meanwhile, his chest CT revealed patchy consolidation and ground-glass opacities localized within the previously irradiated area. Subsequent treatment regimen was adjusted to 80 mg q12h prednisolone with discontinuation of Camrelizumab. Then the symptoms gradually eased and reexamination of CT showed significant improvement in RRP after 2 weeks.Conclusion: Our case report presents a novel pattern of RRP induced by anti-PD-1 blockade Camrelizumab 2 years after radiotherapy. This indicates that previous radiotherapy combined with subsequent anti-PD-1 blockade has a potential to cause overlapping damage to lung, suggesting that intensive attention might be needed for patients who are treated with anti-PD-1 blockade in conjunction with a prior history of thoracic radiation. |
topic |
radiation recall pneumonitis (RRP) anti-PD-1 blockade thoracic radiation immunotherapy Camrelizumab |
url |
https://www.frontiersin.org/article/10.3389/fonc.2020.00561/full |
work_keys_str_mv |
AT yuchen radiationrecallpneumonitisinducedbyantipd1blockadeacasereportandreviewoftheliterature AT yuchen radiationrecallpneumonitisinducedbyantipd1blockadeacasereportandreviewoftheliterature AT zhaoqinhuang radiationrecallpneumonitisinducedbyantipd1blockadeacasereportandreviewoftheliterature AT ligangxing radiationrecallpneumonitisinducedbyantipd1blockadeacasereportandreviewoftheliterature AT xiangjiaomeng radiationrecallpneumonitisinducedbyantipd1blockadeacasereportandreviewoftheliterature AT jinmingyu radiationrecallpneumonitisinducedbyantipd1blockadeacasereportandreviewoftheliterature AT jinmingyu radiationrecallpneumonitisinducedbyantipd1blockadeacasereportandreviewoftheliterature |
_version_ |
1724586761604038656 |