The improved antitumor efficacy of continuous intratumoral chemotherapy with cisplatin-loaded implants for the treatment of sarcoma 180 tumor-bearing mice

The improved antitumor efficacy of continuous intratumoral chemotherapy with cisplatin-loaded implants for the treatment of sarcoma 180 tumor-bearing mice

Cisplatin is the most commonly used antitumor drug in the chemotherapy of a variety of malignancies. However, the severe side effects and drug resistance limit its clinical application. The aim of this study was to develop PLGA-based cisplatin-loaded implants and evaluate the antitumor efficacy of c...

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Bibliographic Details
Main Authors: Li Gao, Shang Cai, Awei Cai, Yang Zhao, Tangbing Xu, Yan Ma, Yan Xu, Yuan Wang, Hao Wang, Yong Hu
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Drug Delivery
Subjects:
cisplatin
implants
sustained release
plga
intratumoral chemotherapy
Online Access:http://dx.doi.org/10.1080/10717544.2019.1574938

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