Computer aided diabetic retinopathy detection based on ophthalmic photography: a systematic review and Meta-analysis
AIM: To ensure the diagnostic value of computer aided techniques in diabetic retinopathy (DR) detection based on ophthalmic photography (OP). METHODS: PubMed, EMBASE, Ei village, IEEE Xplore and Cochrane Library database were searched systematically for literatures about computer aided detection (C...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2019-12-01
|
Series: | International Journal of Ophthalmology |
Subjects: | |
Online Access: | http://www.ijo.cn/en_publish/2019/12/20191214.pdf |
id |
doaj-78d93385dc094cf39ec46bce45501c9c |
---|---|
record_format |
Article |
spelling |
doaj-78d93385dc094cf39ec46bce45501c9c2020-11-25T01:44:11ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982019-12-0112121908191610.18240/ijo.2019.12.14Computer aided diabetic retinopathy detection based on ophthalmic photography: a systematic review and Meta-analysisHui-Qun Wu0Yan-Xing Shan1Huan Wu2Di-Ru Zhu3Hui-Min Tao4Hua-Gen Wei5Xiao-Yan Shen6Ai-Min Sang7Jian-Cheng Dong8Department of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, ChinaDepartment of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, ChinaDepartment of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, ChinaDepartment of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, ChinaDepartment of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, ChinaDepartment of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, ChinaSchool of Information Science and Technology, Nantong University, Nantong 226001, Jiangsu Province, ChinaDepartment of Ophthalmology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, ChinaDepartment of Medical Informatics, Medical School of Nantong University, Nantong 226001, Jiangsu Province, ChinaAIM: To ensure the diagnostic value of computer aided techniques in diabetic retinopathy (DR) detection based on ophthalmic photography (OP). METHODS: PubMed, EMBASE, Ei village, IEEE Xplore and Cochrane Library database were searched systematically for literatures about computer aided detection (CAD) in DR detection. The methodological quality of included studies was appraised by the Quality Assessment Tool for Diagnostic Accuracy Studies (QUADAS-2). Meta-DiSc was utilized and a random effects model was plotted to summarize data from those included studies. Summary receiver operating characteristic curves were selected to estimate the overall test performance. Subgroup analysis was used to identify the efficiency of CAD in detecting DR, exudates (EXs), microaneurysms (MAs) as well as hemorrhages (HMs), and neovascularizations (NVs). Publication bias was analyzed using STATA. RESULTS: Fourteen articles were finally included in this Meta-analysis after literature review. Pooled sensitivity and specificity were 90% (95%CI, 85%-94%) and 90% (95%CI, 80%-96%) respectively for CAD in DR detection. With regard to CAD in EXs detecting, pooled sensitivity, specificity were 89% (95%CI, 88%-90%) and 99% (95%CI, 99%-99%) respectively. In aspect of MAs and HMs detection, pooled sensitivity and specificity of CAD were 42% (95%CI, 41%-44%) and 93% (95%CI, 93%-93%) respectively. Besides, pooled sensitivity and specificity were 94% (95%CI, 89%-97%) and 87% (95%CI, 83%-90%) respectively for CAD in NVs detection. No potential publication bias was observed. CONCLUSION: CAD demonstrates overall high diagnostic accuracy for detecting DR and pathological lesions based on OP. Further prospective clinical trials are needed to prove such effect.http://www.ijo.cn/en_publish/2019/12/20191214.pdfmeta-analysisdiabetic retinopathycomputer aided detection |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hui-Qun Wu Yan-Xing Shan Huan Wu Di-Ru Zhu Hui-Min Tao Hua-Gen Wei Xiao-Yan Shen Ai-Min Sang Jian-Cheng Dong |
spellingShingle |
Hui-Qun Wu Yan-Xing Shan Huan Wu Di-Ru Zhu Hui-Min Tao Hua-Gen Wei Xiao-Yan Shen Ai-Min Sang Jian-Cheng Dong Computer aided diabetic retinopathy detection based on ophthalmic photography: a systematic review and Meta-analysis International Journal of Ophthalmology meta-analysis diabetic retinopathy computer aided detection |
author_facet |
Hui-Qun Wu Yan-Xing Shan Huan Wu Di-Ru Zhu Hui-Min Tao Hua-Gen Wei Xiao-Yan Shen Ai-Min Sang Jian-Cheng Dong |
author_sort |
Hui-Qun Wu |
title |
Computer aided diabetic retinopathy detection based on ophthalmic photography: a systematic review and Meta-analysis |
title_short |
Computer aided diabetic retinopathy detection based on ophthalmic photography: a systematic review and Meta-analysis |
title_full |
Computer aided diabetic retinopathy detection based on ophthalmic photography: a systematic review and Meta-analysis |
title_fullStr |
Computer aided diabetic retinopathy detection based on ophthalmic photography: a systematic review and Meta-analysis |
title_full_unstemmed |
Computer aided diabetic retinopathy detection based on ophthalmic photography: a systematic review and Meta-analysis |
title_sort |
computer aided diabetic retinopathy detection based on ophthalmic photography: a systematic review and meta-analysis |
publisher |
Press of International Journal of Ophthalmology (IJO PRESS) |
series |
International Journal of Ophthalmology |
issn |
2222-3959 2227-4898 |
publishDate |
2019-12-01 |
description |
AIM: To ensure the diagnostic value of computer aided techniques in diabetic retinopathy (DR) detection based on ophthalmic photography (OP).
METHODS: PubMed, EMBASE, Ei village, IEEE Xplore and Cochrane Library database were searched systematically for literatures about computer aided detection (CAD) in DR detection. The methodological quality of included studies was appraised by the Quality Assessment Tool for Diagnostic Accuracy Studies (QUADAS-2). Meta-DiSc was utilized and a random effects model was plotted to summarize data from those included studies. Summary receiver operating characteristic curves were selected to estimate the overall test performance. Subgroup analysis was used to identify the efficiency of CAD in detecting DR, exudates (EXs), microaneurysms (MAs) as well as hemorrhages (HMs), and neovascularizations (NVs). Publication bias was analyzed using STATA.
RESULTS: Fourteen articles were finally included in this Meta-analysis after literature review. Pooled sensitivity and specificity were 90% (95%CI, 85%-94%) and 90% (95%CI, 80%-96%) respectively for CAD in DR detection. With regard to CAD in EXs detecting, pooled sensitivity, specificity were 89% (95%CI, 88%-90%) and 99% (95%CI, 99%-99%) respectively. In aspect of MAs and HMs detection, pooled sensitivity and specificity of CAD were 42% (95%CI, 41%-44%) and 93% (95%CI, 93%-93%) respectively. Besides, pooled sensitivity and specificity were 94% (95%CI, 89%-97%) and 87% (95%CI, 83%-90%) respectively for CAD in NVs detection. No potential publication bias was observed.
CONCLUSION: CAD demonstrates overall high diagnostic accuracy for detecting DR and pathological lesions based on OP. Further prospective clinical trials are needed to prove such effect. |
topic |
meta-analysis diabetic retinopathy computer aided detection |
url |
http://www.ijo.cn/en_publish/2019/12/20191214.pdf |
work_keys_str_mv |
AT huiqunwu computeraideddiabeticretinopathydetectionbasedonophthalmicphotographyasystematicreviewandmetaanalysis AT yanxingshan computeraideddiabeticretinopathydetectionbasedonophthalmicphotographyasystematicreviewandmetaanalysis AT huanwu computeraideddiabeticretinopathydetectionbasedonophthalmicphotographyasystematicreviewandmetaanalysis AT diruzhu computeraideddiabeticretinopathydetectionbasedonophthalmicphotographyasystematicreviewandmetaanalysis AT huimintao computeraideddiabeticretinopathydetectionbasedonophthalmicphotographyasystematicreviewandmetaanalysis AT huagenwei computeraideddiabeticretinopathydetectionbasedonophthalmicphotographyasystematicreviewandmetaanalysis AT xiaoyanshen computeraideddiabeticretinopathydetectionbasedonophthalmicphotographyasystematicreviewandmetaanalysis AT aiminsang computeraideddiabeticretinopathydetectionbasedonophthalmicphotographyasystematicreviewandmetaanalysis AT jianchengdong computeraideddiabeticretinopathydetectionbasedonophthalmicphotographyasystematicreviewandmetaanalysis |
_version_ |
1725029301410070528 |