Effect of L-arginine, dimercaptosuccinic acid (DMSA) and the association of L-arginine and DMSA on tissue lead mobilization and blood pressure level in plumbism

Effect of L-arginine, dimercaptosuccinic acid (DMSA) and the association of L-arginine and DMSA on tissue lead mobilization and blood pressure level in plumbism

Lead (Pb)-induced hypertension is characterized by an increase in reactive oxygen species (ROS) and a decrease in nitric oxide (NO). In the present study we evaluated the effect of L-arginine (NO precursor), dimercaptosuccinic acid (DMSA, a chelating agent and ROS scavenger), and the association of...

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Bibliographic Details
Main Authors: C.K. Malvezzi, E.G. Moreira, I. Vassilieff, V.S. Vassilieff, S. Cordellini
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2001-10-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
L-arginine
DMSA
tissue lead mobilization
plumbism
blood pressure
rat
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001000016

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