The spliceosome pathway activity correlates with reduced anti-tumor immunity and immunotherapy response, and unfavorable clinical outcomes in pan-cancer
Alterations in the spliceosome pathway (SP) have been associated with diverse human cancers. In this study, we explored associations of the SP activity with various clinical features, anti-tumor immune signatures, tumor immunity-related genomic and molecular features, and the response to immunothera...
Main Authors: | Zuobing Chen, Canping Chen, Lin Li, Tianfang Zhang, Xiaosheng Wang |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-01-01
|
Series: | Computational and Structural Biotechnology Journal |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037021004141 |
Similar Items
-
Pan-Cancer Analysis Reveals That E1A Binding Protein p300 Mutations Increase Genome Instability and Antitumor Immunity
by: Zuobing Chen, et al.
Published: (2021-09-01) -
IDENTIFICATION AND CHARACTERIZATION OF COMPONENTS OF THE YEAST SPLICEOSOME
by: Pandit, Shatakshi Shreekant
Published: (2007) -
Patterns of conservation of spliceosomal intron structures and spliceosome divergence in representatives of the diplomonad and parabasalid lineages
by: Andrew J. Hudson, et al.
Published: (2019-08-01) -
Emergence and loss of spliceosomal twin introns
by: Michel Flipphi, et al.
Published: (2017-10-01) -
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures
by: Xinke Zhang, et al.
Published: (2021-08-01)