Stem Cell-Based Therapies in Chagasic Cardiomyopathy

Stem Cell-Based Therapies in Chagasic Cardiomyopathy

Chagas disease is caused by Trypanosoma cruzi and can lead to a dilated cardiomyopathy decades after the prime infection by the parasite. As with other dilated cardiomyopathies, conventional pharmacologic therapies are not always effective and as heart failure progresses patients need heart transpla...

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Main Authors: Antonio Carlos Campos de Carvalho, Adriana Bastos Carvalho
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/436314
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spelling doaj-78f603e903554d1fb386eec1770341ea2020-11-24T21:11:57ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/436314436314Stem Cell-Based Therapies in Chagasic CardiomyopathyAntonio Carlos Campos de Carvalho0Adriana Bastos Carvalho1Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rua Carlos Chagas Filho 373, 21949-900 Rio de Janeiro, RJ, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rua Carlos Chagas Filho 373, 21949-900 Rio de Janeiro, RJ, BrazilChagas disease is caused by Trypanosoma cruzi and can lead to a dilated cardiomyopathy decades after the prime infection by the parasite. As with other dilated cardiomyopathies, conventional pharmacologic therapies are not always effective and as heart failure progresses patients need heart transplantation. Therefore alternative therapies are highly desirable and cell-based therapies have been investigated in preclinical and clinical studies. In this paper we review the main findings of such studies and discuss future directions for stem cell-based therapies in chronic chagasic cardiomyopathy.http://dx.doi.org/10.1155/2015/436314
collection DOAJ
language English
format Article
sources DOAJ
author Antonio Carlos Campos de Carvalho
Adriana Bastos Carvalho
spellingShingle Antonio Carlos Campos de Carvalho
Adriana Bastos Carvalho
Stem Cell-Based Therapies in Chagasic Cardiomyopathy
BioMed Research International
author_facet Antonio Carlos Campos de Carvalho
Adriana Bastos Carvalho
author_sort Antonio Carlos Campos de Carvalho
title Stem Cell-Based Therapies in Chagasic Cardiomyopathy
title_short Stem Cell-Based Therapies in Chagasic Cardiomyopathy
title_full Stem Cell-Based Therapies in Chagasic Cardiomyopathy
title_fullStr Stem Cell-Based Therapies in Chagasic Cardiomyopathy
title_full_unstemmed Stem Cell-Based Therapies in Chagasic Cardiomyopathy
title_sort stem cell-based therapies in chagasic cardiomyopathy
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2015-01-01
description Chagas disease is caused by Trypanosoma cruzi and can lead to a dilated cardiomyopathy decades after the prime infection by the parasite. As with other dilated cardiomyopathies, conventional pharmacologic therapies are not always effective and as heart failure progresses patients need heart transplantation. Therefore alternative therapies are highly desirable and cell-based therapies have been investigated in preclinical and clinical studies. In this paper we review the main findings of such studies and discuss future directions for stem cell-based therapies in chronic chagasic cardiomyopathy.
url http://dx.doi.org/10.1155/2015/436314
work_keys_str_mv AT antoniocarloscamposdecarvalho stemcellbasedtherapiesinchagasiccardiomyopathy
AT adrianabastoscarvalho stemcellbasedtherapiesinchagasiccardiomyopathy
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