A report of two children with Gorham-Stout disease
Abstract Background Gorham-Stout disease is a rare condition characterized by unifocal and massive type IV osteolysis (variant of idiopathic nonhereditary osteolytic disease) with a slow progression, which is self-limiting for some years. It is characterized by recurrent vascular tumors with disrupt...
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doaj-78f60f6545df4915be987f8c1fd44a872020-11-25T03:16:28ZengBMCBMC Pediatrics1471-24312019-06-011911710.1186/s12887-019-1561-0A report of two children with Gorham-Stout diseaseMario Edgar Tena-Sanabria0Larisa Yarindy Jesús-Mejenes1Gabriela Fuentes-Herrera2Félix Alejandro Álvarez-Martínez3Nora Patricia Victorio-García4Juan Carlos Núñez-Enríquez5Unidad Médica de Alta Especialidad, Servicio de Ortopedia Pediátrica, Hospital de Pediatría “Dr. Silvestre Frenk Freund”, Centro Médico Nacional “Siglo XXI”, Instituto Mexicano del Seguro SocialUnidad Médica de Alta Especialidad, Servicio de Ortopedia Pediátrica, Hospital de Pediatría “Dr. Silvestre Frenk Freund”, Centro Médico Nacional “Siglo XXI”, Instituto Mexicano del Seguro SocialUnidad Médica de Alta Especialidad, Servicio de Ortopedia Pediátrica, Hospital de Pediatría “Dr. Silvestre Frenk Freund”, Centro Médico Nacional “Siglo XXI”, Instituto Mexicano del Seguro SocialUnidad Médica de Alta Especialidad, Servicio de Ortopedia Pediátrica, Hospital de Pediatría “Dr. Silvestre Frenk Freund”, Centro Médico Nacional “Siglo XXI”, Instituto Mexicano del Seguro SocialUnidad de Investigación en Epidemiología Clínica, Hospital de Pediatría “Dr. Silvestre Frenk Freund”, Centro Médico Nacional “Siglo XXI”, Instituto Mexicano del Seguro SocialUnidad de Investigación en Epidemiología Clínica, Hospital de Pediatría “Dr. Silvestre Frenk Freund”, Centro Médico Nacional “Siglo XXI”, Instituto Mexicano del Seguro SocialAbstract Background Gorham-Stout disease is a rare condition characterized by unifocal and massive type IV osteolysis (variant of idiopathic nonhereditary osteolytic disease) with a slow progression, which is self-limiting for some years. It is characterized by recurrent vascular tumors with disruption of the anatomical architecture and intraosseous proliferation of vascular channels that leads to the destruction and resorption of the bone matrix. The aim of this study is to present the clinical features of this disease, as well as the importance of prompt diagnosis and treatment, with a review of the reported cases. Case reports We describe two cases of Gorham-Stout disease between 2013 and 2017 with surgical interventions, follow-up and results. Case one involves an 11-year-old male with involvement of the left iliac bone, with adequate evolution after a surgical procedure with a lyophilized cadaveric tricortical bone allograft. Case two involves a 6-year-old male with cervical spine C1-C3 repercussion; in the protocol for surgical treatment, he presented with signs of spinal cord compression and died. Conclusion Diagnosis of Gorham-Stout disease is made by exclusion, and its clinical presentation varies widely, from spontaneous remission to a fatal outcome.http://link.springer.com/article/10.1186/s12887-019-1561-0Gorham-stout diseaseIdiopathic osteolysisChildrenPediatric orthopedics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mario Edgar Tena-Sanabria Larisa Yarindy Jesús-Mejenes Gabriela Fuentes-Herrera Félix Alejandro Álvarez-Martínez Nora Patricia Victorio-García Juan Carlos Núñez-Enríquez |
spellingShingle |
Mario Edgar Tena-Sanabria Larisa Yarindy Jesús-Mejenes Gabriela Fuentes-Herrera Félix Alejandro Álvarez-Martínez Nora Patricia Victorio-García Juan Carlos Núñez-Enríquez A report of two children with Gorham-Stout disease BMC Pediatrics Gorham-stout disease Idiopathic osteolysis Children Pediatric orthopedics |
author_facet |
Mario Edgar Tena-Sanabria Larisa Yarindy Jesús-Mejenes Gabriela Fuentes-Herrera Félix Alejandro Álvarez-Martínez Nora Patricia Victorio-García Juan Carlos Núñez-Enríquez |
author_sort |
Mario Edgar Tena-Sanabria |
title |
A report of two children with Gorham-Stout disease |
title_short |
A report of two children with Gorham-Stout disease |
title_full |
A report of two children with Gorham-Stout disease |
title_fullStr |
A report of two children with Gorham-Stout disease |
title_full_unstemmed |
A report of two children with Gorham-Stout disease |
title_sort |
report of two children with gorham-stout disease |
publisher |
BMC |
series |
BMC Pediatrics |
issn |
1471-2431 |
publishDate |
2019-06-01 |
description |
Abstract Background Gorham-Stout disease is a rare condition characterized by unifocal and massive type IV osteolysis (variant of idiopathic nonhereditary osteolytic disease) with a slow progression, which is self-limiting for some years. It is characterized by recurrent vascular tumors with disruption of the anatomical architecture and intraosseous proliferation of vascular channels that leads to the destruction and resorption of the bone matrix. The aim of this study is to present the clinical features of this disease, as well as the importance of prompt diagnosis and treatment, with a review of the reported cases. Case reports We describe two cases of Gorham-Stout disease between 2013 and 2017 with surgical interventions, follow-up and results. Case one involves an 11-year-old male with involvement of the left iliac bone, with adequate evolution after a surgical procedure with a lyophilized cadaveric tricortical bone allograft. Case two involves a 6-year-old male with cervical spine C1-C3 repercussion; in the protocol for surgical treatment, he presented with signs of spinal cord compression and died. Conclusion Diagnosis of Gorham-Stout disease is made by exclusion, and its clinical presentation varies widely, from spontaneous remission to a fatal outcome. |
topic |
Gorham-stout disease Idiopathic osteolysis Children Pediatric orthopedics |
url |
http://link.springer.com/article/10.1186/s12887-019-1561-0 |
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