The efficacy and safety of urethral injection therapy for urinary incontinence in women: a systematic review
To evaluate the efficacy and safety of different bulking agents for treating urinary incontinence in women, a systematic review including only randomized controlled trials was performed. The subjects were women with urinary incontinence. The primary outcomes were clinical and urodynamic parameters....
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Faculdade de Medicina / USP
2016-02-01
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doaj-78fa3521d0334d07bbaf3b6aa65a51702020-11-24T21:06:10ZengFaculdade de Medicina / USPClinics1980-53222016-02-017129410010.6061/clinics/2016(02)08S1807-59322016000200094The efficacy and safety of urethral injection therapy for urinary incontinence in women: a systematic reviewPriscila Katsumi MatsuokaRafael Fagionato LocaliAparecida Maria PacettaEdmund Chada BaracatJorge Milhem HaddadTo evaluate the efficacy and safety of different bulking agents for treating urinary incontinence in women, a systematic review including only randomized controlled trials was performed. The subjects were women with urinary incontinence. The primary outcomes were clinical and urodynamic parameters. The results were presented as a weighted mean difference for non-continuous variables and as relative risk for continuous variables, both with 95% confidence intervals. Initially, 942 studies were identified. However, only fourteen eligible trials fulfilled the prerequisites. Altogether, the review included 1814 patients in trials of eight different types of bulking agents, and all studies were described and analyzed. The measured outcomes were evaluated using a large variety of instruments. The most common complications of the bulking agents were urinary retention and urinary tract infection. Additionally, there were certain major complications, such as one case of death after use of autologous fat. However, the lack of adequate studies, the heterogeneous populations studied, the wide variety of materials used and the lack of long-term follow-up limit guidance of practice. To determine which substance is the most suitable, there is a need for more randomized clinical trials that compare existing bulking agents based on standardized clinical outcomes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322016000200094&lng=en&tlng=enBulking AgentsInjectionsIntraurethral InjectionsUrinary Incontinence |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Priscila Katsumi Matsuoka Rafael Fagionato Locali Aparecida Maria Pacetta Edmund Chada Baracat Jorge Milhem Haddad |
spellingShingle |
Priscila Katsumi Matsuoka Rafael Fagionato Locali Aparecida Maria Pacetta Edmund Chada Baracat Jorge Milhem Haddad The efficacy and safety of urethral injection therapy for urinary incontinence in women: a systematic review Clinics Bulking Agents Injections Intraurethral Injections Urinary Incontinence |
author_facet |
Priscila Katsumi Matsuoka Rafael Fagionato Locali Aparecida Maria Pacetta Edmund Chada Baracat Jorge Milhem Haddad |
author_sort |
Priscila Katsumi Matsuoka |
title |
The efficacy and safety of urethral injection therapy for urinary incontinence in women: a systematic review |
title_short |
The efficacy and safety of urethral injection therapy for urinary incontinence in women: a systematic review |
title_full |
The efficacy and safety of urethral injection therapy for urinary incontinence in women: a systematic review |
title_fullStr |
The efficacy and safety of urethral injection therapy for urinary incontinence in women: a systematic review |
title_full_unstemmed |
The efficacy and safety of urethral injection therapy for urinary incontinence in women: a systematic review |
title_sort |
efficacy and safety of urethral injection therapy for urinary incontinence in women: a systematic review |
publisher |
Faculdade de Medicina / USP |
series |
Clinics |
issn |
1980-5322 |
publishDate |
2016-02-01 |
description |
To evaluate the efficacy and safety of different bulking agents for treating urinary incontinence in women, a systematic review including only randomized controlled trials was performed. The subjects were women with urinary incontinence. The primary outcomes were clinical and urodynamic parameters. The results were presented as a weighted mean difference for non-continuous variables and as relative risk for continuous variables, both with 95% confidence intervals. Initially, 942 studies were identified. However, only fourteen eligible trials fulfilled the prerequisites. Altogether, the review included 1814 patients in trials of eight different types of bulking agents, and all studies were described and analyzed. The measured outcomes were evaluated using a large variety of instruments. The most common complications of the bulking agents were urinary retention and urinary tract infection. Additionally, there were certain major complications, such as one case of death after use of autologous fat. However, the lack of adequate studies, the heterogeneous populations studied, the wide variety of materials used and the lack of long-term follow-up limit guidance of practice. To determine which substance is the most suitable, there is a need for more randomized clinical trials that compare existing bulking agents based on standardized clinical outcomes. |
topic |
Bulking Agents Injections Intraurethral Injections Urinary Incontinence |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322016000200094&lng=en&tlng=en |
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