TAT-Conjugated NDUFS8 Can Be Transduced into Mitochondria in a Membrane-Potential-Independent Manner and Rescue Complex I Deficiency

TAT-Conjugated NDUFS8 Can Be Transduced into Mitochondria in a Membrane-Potential-Independent Manner and Rescue Complex I Deficiency

NADH dehydrogenase (ubiquinone) Fe-S protein 8 (NDUFS8) is a nuclear-encoded core subunit of human mitochondrial complex I. Defects in NDUFS8 are associated with Leigh syndrome and encephalomyopathy. Cell-penetrating peptide derived from the HIV-1 transactivator of transcription protein (TAT) has be...

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Bibliographic Details
Main Authors: Bo-Yu Lin, Gui-Teng Zheng, Kai-Wen Teng, Juan-Yu Chang, Chao-Chang Lee, Pin-Chao Liao, Mou-Chieh Kao
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondria
complex I
NDUFS8
protein transduction domain
HIV-1 transactivator of transcription peptide (TAT)
enzyme replacement therapy
Online Access:https://www.mdpi.com/1422-0067/22/12/6524

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https://www.mdpi.com/1422-0067/22/12/6524

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