Cytotoxic effects of selective species of Caryophyllaceae in Iran
Cancer is a major cause of death worldwide and causes serious problems in human life. It is developed by uncontrolled growth of a cell or a group of cells. There are many difficulties in treatment of cancer and many researchers are involved in investigating for effective drugs to treat the disease....
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doaj-7906e8ba636a432c85265b402fcfdc6c2020-11-24T22:31:09ZengIranian Society of PharmacognosyResearch Journal of Pharmacognosy2345-44582345-59772014-04-011229324758Cytotoxic effects of selective species of Caryophyllaceae in IranF. Naghibi0M. Irani1A. Hassanpour2A. Pirani3M. Hamzeloo-Moghadam4Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Cancer is a major cause of death worldwide and causes serious problems in human life. It is developed by uncontrolled growth of a cell or a group of cells. There are many difficulties in treatment of cancer and many researchers are involved in investigating for effective drugs to treat the disease. Caryophyllaceae is a large family of about 86 genera and 2200 herbaceous or subshrub species. The family is known for its ornamental plants and saponin compounds. In the present study, the potential cytotoxic activity of 17 selected species from Caryophyllaceae has been investigated against MCF-7, HepG-2, A-549, HT-29 and MDBK cells using MTT assay. Five species exhibited cytotoxic effects with IC50 values < 100 μg/mL. Silene ampullata and Acanthophyllum bracteatum extracts were toxic only against MCF-7 cell line suggesting them as suitable candidates for more investigations of breast cancer studies.http://www.rjpharmacognosy.ir/pdf_4758_44aeedd35d408e5104b75da1e4e1977b.htmlCaryophyllaceaecytotoxic activityMTT assay |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
F. Naghibi M. Irani A. Hassanpour A. Pirani M. Hamzeloo-Moghadam |
spellingShingle |
F. Naghibi M. Irani A. Hassanpour A. Pirani M. Hamzeloo-Moghadam Cytotoxic effects of selective species of Caryophyllaceae in Iran Research Journal of Pharmacognosy Caryophyllaceae cytotoxic activity MTT assay |
author_facet |
F. Naghibi M. Irani A. Hassanpour A. Pirani M. Hamzeloo-Moghadam |
author_sort |
F. Naghibi |
title |
Cytotoxic effects of selective species of Caryophyllaceae in Iran |
title_short |
Cytotoxic effects of selective species of Caryophyllaceae in Iran |
title_full |
Cytotoxic effects of selective species of Caryophyllaceae in Iran |
title_fullStr |
Cytotoxic effects of selective species of Caryophyllaceae in Iran |
title_full_unstemmed |
Cytotoxic effects of selective species of Caryophyllaceae in Iran |
title_sort |
cytotoxic effects of selective species of caryophyllaceae in iran |
publisher |
Iranian Society of Pharmacognosy |
series |
Research Journal of Pharmacognosy |
issn |
2345-4458 2345-5977 |
publishDate |
2014-04-01 |
description |
Cancer is a major cause of death worldwide and causes serious problems in human life. It is developed by uncontrolled growth of a cell or a group of cells. There are many difficulties in treatment of cancer and many researchers are involved in investigating for effective drugs to treat the disease. Caryophyllaceae is a large family of about 86 genera and 2200 herbaceous or subshrub species. The family is known for its ornamental plants and saponin compounds. In the present study, the potential cytotoxic activity of 17 selected species from Caryophyllaceae has been investigated against MCF-7, HepG-2, A-549, HT-29 and MDBK cells using MTT assay. Five species exhibited cytotoxic effects with IC50 values < 100 μg/mL. Silene ampullata and Acanthophyllum bracteatum extracts were toxic only against MCF-7 cell line suggesting them as suitable candidates for more investigations of breast cancer studies. |
topic |
Caryophyllaceae cytotoxic activity MTT assay |
url |
http://www.rjpharmacognosy.ir/pdf_4758_44aeedd35d408e5104b75da1e4e1977b.html |
work_keys_str_mv |
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