Varions Mechanisms of Deubiquitinating Enzyme USP22 in Cancer
Ubiquitin specific proteases 22 (USP22) is a highly conserved ubiquitin hydrolase in mammals. It mainly prevents proteins degradation by deubiquitinating substrate proteins and regulates life processes such as genetic transcription, DNA damage repair and embryonic development. USP22 has been proved...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Magazine House of Cancer Research on Prevention and Treatment
2020-12-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://html.rhhz.net/ZLFZYJ/html/8578.2020.20.0270.htm |
| Summary: | Ubiquitin specific proteases 22 (USP22) is a highly conserved ubiquitin hydrolase in mammals. It mainly prevents proteins degradation by deubiquitinating substrate proteins and regulates life processes such as genetic transcription, DNA damage repair and embryonic development. USP22 has been proved to promote cancer development by regulating multiple signal pathways. This article focuses on the relevant mechanisms of USP22 regulating tumorigenesis and development through deubiquitinating modification. |
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| ISSN: | 1000-8578 1000-8578 |