Association between serum albumin and glycated hemoglobin in Asian Indian subjects
Background: Protein glycation plays a signifi cant role in diabetic complications. Glycated hemoglobin (HbA1c) is a known predictor of diabetes and its complications. Albumin, found to be profoundly glycated in diabetes, and its level could regulate plasma protein as well as hemoglobin glycation. Ai...
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doaj-790bb96def35489bb697e46f342f23b22020-11-24T21:19:20ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002015-01-01191525510.4103/2230-8210.144631Association between serum albumin and glycated hemoglobin in Asian Indian subjectsShalbha TiwariManish BothaleImtiaz HasanMahesh J KulkarniMehmood G SayyadRita BasuAnanda BasuAmbika Gopalakrishnan UnnikrishnanBackground: Protein glycation plays a signifi cant role in diabetic complications. Glycated hemoglobin (HbA1c) is a known predictor of diabetes and its complications. Albumin, found to be profoundly glycated in diabetes, and its level could regulate plasma protein as well as hemoglobin glycation. Aim: We aimed to evaluate the association between variations in albumin level with HbA1c in the Asian Indian population. Materials and Methods: We screened data of 929 subjects who have had a simultaneous measurement of fasting plasma glucose (FPG), HbA1c and albumin levels via the same blood collection. Data were analyzed by SPSS for 610 subjects who met the study criteria. Results: There was a signifi cant negative correlation between HbA1c and albumin concentration (r = −0.284; P < 0.001). Univariate analysis showed the statistically signifi cant decrease of average HbA1c but not for fasting plasma glucose (FPG) across increasing tertiles of albumin. Stepwise multiple regression model showed a signifi cant correlation between HbA1c and serum albumin (P < 0.05), FPG (P < 0.001), hemoglobin (Hb) (P < 0.001) and serum globulin (P < 0.05). FPG was the strongest predictor (63.4%) of variation of HbA1c. The albumin concentration (r = −0.114) accounted for 0.3% (P < 0.05) of the total variance in HbA1c independent of age, body mass index, FPG, Hb, creatinine, total protein and globulin. It was also observed that HbA1c decreases with increasing albumin concentration in those having FPG between 100 to <126 mg/dl. Conclusion: Serum albumin negatively correlates with HbA1c in Asian Indians independent of other variables. This study suggests that predicting diabetes and its complication based on the HbA1c needs to be further investigated in Indian subjects.http://www.ijem.in/article.asp?issn=2230-8210;year=2015;volume=19;issue=1;spage=52;epage=55;aulast=TiwariAlbuminglycated hemoglobinglycation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shalbha Tiwari Manish Bothale Imtiaz Hasan Mahesh J Kulkarni Mehmood G Sayyad Rita Basu Ananda Basu Ambika Gopalakrishnan Unnikrishnan |
spellingShingle |
Shalbha Tiwari Manish Bothale Imtiaz Hasan Mahesh J Kulkarni Mehmood G Sayyad Rita Basu Ananda Basu Ambika Gopalakrishnan Unnikrishnan Association between serum albumin and glycated hemoglobin in Asian Indian subjects Indian Journal of Endocrinology and Metabolism Albumin glycated hemoglobin glycation |
author_facet |
Shalbha Tiwari Manish Bothale Imtiaz Hasan Mahesh J Kulkarni Mehmood G Sayyad Rita Basu Ananda Basu Ambika Gopalakrishnan Unnikrishnan |
author_sort |
Shalbha Tiwari |
title |
Association between serum albumin and glycated hemoglobin in Asian Indian subjects |
title_short |
Association between serum albumin and glycated hemoglobin in Asian Indian subjects |
title_full |
Association between serum albumin and glycated hemoglobin in Asian Indian subjects |
title_fullStr |
Association between serum albumin and glycated hemoglobin in Asian Indian subjects |
title_full_unstemmed |
Association between serum albumin and glycated hemoglobin in Asian Indian subjects |
title_sort |
association between serum albumin and glycated hemoglobin in asian indian subjects |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Endocrinology and Metabolism |
issn |
2230-8210 2230-9500 |
publishDate |
2015-01-01 |
description |
Background: Protein glycation plays a signifi cant role in diabetic complications. Glycated hemoglobin (HbA1c) is a known predictor of diabetes and its complications. Albumin, found to be profoundly glycated in diabetes, and its level could regulate plasma protein as well as hemoglobin glycation. Aim: We aimed to evaluate the association between variations in albumin level with HbA1c in the Asian Indian population. Materials and Methods: We screened data of 929 subjects who have had a simultaneous measurement of fasting plasma glucose (FPG), HbA1c and albumin levels via the same blood collection. Data were analyzed by SPSS for 610 subjects who met the study criteria. Results: There was a signifi cant negative correlation between HbA1c and albumin concentration (r = −0.284; P < 0.001). Univariate analysis showed the statistically signifi cant decrease of average HbA1c but not for fasting plasma glucose (FPG) across increasing tertiles of albumin. Stepwise multiple regression model showed a signifi cant correlation between HbA1c and serum albumin (P < 0.05), FPG (P < 0.001), hemoglobin (Hb) (P < 0.001) and serum globulin (P < 0.05). FPG was the strongest predictor (63.4%) of variation of HbA1c. The albumin concentration (r = −0.114) accounted for 0.3% (P < 0.05) of the total variance in HbA1c independent of age, body mass index, FPG, Hb, creatinine, total protein and globulin. It was also observed that HbA1c decreases with increasing albumin concentration in those having FPG between 100 to <126 mg/dl. Conclusion: Serum albumin negatively correlates with HbA1c in Asian Indians independent of other variables. This study suggests that predicting diabetes and its complication based on the HbA1c needs to be further investigated in Indian subjects. |
topic |
Albumin glycated hemoglobin glycation |
url |
http://www.ijem.in/article.asp?issn=2230-8210;year=2015;volume=19;issue=1;spage=52;epage=55;aulast=Tiwari |
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