Spontaneous and continuous anti-virus disinfection from nonstoichiometric perovskite-type lanthanum manganese oxide
Viral pathogens have threatened human being׳s health for a long time, from periodically breakout flu epidemics to recent rising Ebola virus disease. Herein, we report a new application of nonstoichiometric Perovskite-type LaxMnO3 (x=1, 0.95, and 0.9) compounds in spontaneous and continuous disinfect...
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doaj-7912cbcc9041475cb4d15e79dc1dd9fc2020-11-24T22:23:54ZengElsevierProgress in Natural Science: Materials International1002-00712015-06-0125319119610.1016/j.pnsc.2015.05.003Spontaneous and continuous anti-virus disinfection from nonstoichiometric perovskite-type lanthanum manganese oxideDing Weng0Chao Lei1Ting-Ting Wu2Ren Sun3Meiqing Shen4Yunfeng Lu5Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, United StatesDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, United StatesDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USKey Laboratory for Green Chemical Technology of State Education Ministry, School of Chemical Engineering and Technology and State Key Laboratory of Engines, Tianjin University, Tianjin 300072, ChinaDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, United StatesViral pathogens have threatened human being׳s health for a long time, from periodically breakout flu epidemics to recent rising Ebola virus disease. Herein, we report a new application of nonstoichiometric Perovskite-type LaxMnO3 (x=1, 0.95, and 0.9) compounds in spontaneous and continuous disinfection of viruses. Perovskite-type LaxMnO3 (x=1, 0.95, and 0.9) is well-known for their catalytic properties involving oxidization reactions, which are usually utilized as electrodes in fuel cells. By utilizing superb oxidative ability of LaxMnO3 (x=1, 0.95, and 0.9), amino acid residues in viral envelope proteins are oxidized, thus envelope proteins are denatured and infectivity of the virus is neutralized. It is of great importance that this process does not require external energy sources like light or heat. The A/PR/8/34H1N1 influenza A virus (PR8) was employed as the sample virus in our demonstration, and high-throughput disinfections were observed. The efficiency of disinfection was correlated to oxidative ability of LaxMnO3 (x=1, 0.95, and 0.9) by EPR and H2-TPR results that La0.9MnO3 had the highest oxidative ability and correspondingly gave out the best disinfecting results within three nonstoichiometric compounds. Moreover, denaturation of hemagglutinin and neuraminidase, the two key envelope proteins of influenza A viruses, was demonstrated by HA unit assay with chicken red blood cells and NA fluorescence assay, respectively. This unique disinfecting application of La0.9MnO3 is considered as a great make up to current sterilizing methods especially to photocatalyst based disinfectants and can be widely applied to cut-off spread routes of viruses, either viral aerosol or contaminated fluid, and help in controlling the possibly upcoming epidemics like flus and hemorrhagic fever.http://www.sciencedirect.com/science/article/pii/S1002007115000519DisinfectInfluenza A virusLaxMnO3NonstoichiometricPerovskite |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ding Weng Chao Lei Ting-Ting Wu Ren Sun Meiqing Shen Yunfeng Lu |
spellingShingle |
Ding Weng Chao Lei Ting-Ting Wu Ren Sun Meiqing Shen Yunfeng Lu Spontaneous and continuous anti-virus disinfection from nonstoichiometric perovskite-type lanthanum manganese oxide Progress in Natural Science: Materials International Disinfect Influenza A virus LaxMnO3 Nonstoichiometric Perovskite |
author_facet |
Ding Weng Chao Lei Ting-Ting Wu Ren Sun Meiqing Shen Yunfeng Lu |
author_sort |
Ding Weng |
title |
Spontaneous and continuous anti-virus disinfection from nonstoichiometric perovskite-type lanthanum manganese oxide |
title_short |
Spontaneous and continuous anti-virus disinfection from nonstoichiometric perovskite-type lanthanum manganese oxide |
title_full |
Spontaneous and continuous anti-virus disinfection from nonstoichiometric perovskite-type lanthanum manganese oxide |
title_fullStr |
Spontaneous and continuous anti-virus disinfection from nonstoichiometric perovskite-type lanthanum manganese oxide |
title_full_unstemmed |
Spontaneous and continuous anti-virus disinfection from nonstoichiometric perovskite-type lanthanum manganese oxide |
title_sort |
spontaneous and continuous anti-virus disinfection from nonstoichiometric perovskite-type lanthanum manganese oxide |
publisher |
Elsevier |
series |
Progress in Natural Science: Materials International |
issn |
1002-0071 |
publishDate |
2015-06-01 |
description |
Viral pathogens have threatened human being׳s health for a long time, from periodically breakout flu epidemics to recent rising Ebola virus disease. Herein, we report a new application of nonstoichiometric Perovskite-type LaxMnO3 (x=1, 0.95, and 0.9) compounds in spontaneous and continuous disinfection of viruses. Perovskite-type LaxMnO3 (x=1, 0.95, and 0.9) is well-known for their catalytic properties involving oxidization reactions, which are usually utilized as electrodes in fuel cells. By utilizing superb oxidative ability of LaxMnO3 (x=1, 0.95, and 0.9), amino acid residues in viral envelope proteins are oxidized, thus envelope proteins are denatured and infectivity of the virus is neutralized. It is of great importance that this process does not require external energy sources like light or heat. The A/PR/8/34H1N1 influenza A virus (PR8) was employed as the sample virus in our demonstration, and high-throughput disinfections were observed. The efficiency of disinfection was correlated to oxidative ability of LaxMnO3 (x=1, 0.95, and 0.9) by EPR and H2-TPR results that La0.9MnO3 had the highest oxidative ability and correspondingly gave out the best disinfecting results within three nonstoichiometric compounds. Moreover, denaturation of hemagglutinin and neuraminidase, the two key envelope proteins of influenza A viruses, was demonstrated by HA unit assay with chicken red blood cells and NA fluorescence assay, respectively. This unique disinfecting application of La0.9MnO3 is considered as a great make up to current sterilizing methods especially to photocatalyst based disinfectants and can be widely applied to cut-off spread routes of viruses, either viral aerosol or contaminated fluid, and help in controlling the possibly upcoming epidemics like flus and hemorrhagic fever. |
topic |
Disinfect Influenza A virus LaxMnO3 Nonstoichiometric Perovskite |
url |
http://www.sciencedirect.com/science/article/pii/S1002007115000519 |
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